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Exploring molecular diversity with combinatorial shape libraries.

Publication ,  Journal Article
Kenan, DJ; Tsai, DE; Keene, JD
Published in: Trends Biochem Sci
February 1994

Surface technologies based upon selection of ligands from combinatorial libraries herald a revolution in molecular research and drug discovery. Molecular diversity is generated by random combinations of monomeric building blocks to form polymeric conformers that constitute 'shape libraries'. The media for exploring surfaces of target molecules include synthetic or biological polymers consisting of natural or modified amino acids, nucleotides, carbohydrates and other organic materials. Targets can be any biological surface, including enzymes, antibodies, receptors and other regulatory molecules. The power of combinatorial selection is in finding conceptual leads for designing high-affinity ligands and effector molecules for the analysis and manipulation of biochemical interactions.

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Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

February 1994

Volume

19

Issue

2

Start / End Page

57 / 64

Location

England

Related Subject Headings

  • RNA-Binding Proteins
  • Protein Binding
  • Oligonucleotides
  • Nucleic Acids
  • Ligands
  • Genetic Variation
  • Genetic Techniques
  • Gene Library
  • Developmental Biology
  • Biological Evolution
 

Citation

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Kenan, D. J., Tsai, D. E., & Keene, J. D. (1994). Exploring molecular diversity with combinatorial shape libraries. Trends Biochem Sci, 19(2), 57–64. https://doi.org/10.1016/0968-0004(94)90033-7
Kenan, D. J., D. E. Tsai, and J. D. Keene. “Exploring molecular diversity with combinatorial shape libraries.Trends Biochem Sci 19, no. 2 (February 1994): 57–64. https://doi.org/10.1016/0968-0004(94)90033-7.
Kenan DJ, Tsai DE, Keene JD. Exploring molecular diversity with combinatorial shape libraries. Trends Biochem Sci. 1994 Feb;19(2):57–64.
Kenan, D. J., et al. “Exploring molecular diversity with combinatorial shape libraries.Trends Biochem Sci, vol. 19, no. 2, Feb. 1994, pp. 57–64. Pubmed, doi:10.1016/0968-0004(94)90033-7.
Kenan DJ, Tsai DE, Keene JD. Exploring molecular diversity with combinatorial shape libraries. Trends Biochem Sci. 1994 Feb;19(2):57–64.
Journal cover image

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

February 1994

Volume

19

Issue

2

Start / End Page

57 / 64

Location

England

Related Subject Headings

  • RNA-Binding Proteins
  • Protein Binding
  • Oligonucleotides
  • Nucleic Acids
  • Ligands
  • Genetic Variation
  • Genetic Techniques
  • Gene Library
  • Developmental Biology
  • Biological Evolution