Initial testing of aplidin by the pediatric pre-clinical testing program.


Journal Article

Aplidin was tested in vitro at concentrations ranging from from 0.1 nM to 1.0 microM and in vivo at a dose of 0.6 mg/kg administered intraperitoneally on an every 4 days x 3-schedule that was repeated at day 21. In vitro, Aplidin was most active against acute lymphoblastic leukemia (ALL) cell lines. In vivo, Aplidin induced significant differences in EFS distribution in 12 of 28 (43%) solid tumor models and 2 of 6 evaluable ALL models. Aplidin showed potent in vitro activity and induced significant in vivo tumor growth inhibition in some xenografts, but did not induce tumor regressions.

Full Text

Duke Authors

Cited Authors

  • Morton, CL; Houghton, PJ; Gorlick, R; Kolb, EA; Lock, R; Carol, H; Keir, ST; Reynolds, CP; Kang, MH; Maris, JM; Billups, C; Smith, MA

Published Date

  • September 2009

Published In

Volume / Issue

  • 53 / 3

Start / End Page

  • 509 - 512

PubMed ID

  • 19418543

Pubmed Central ID

  • 19418543

Electronic International Standard Serial Number (EISSN)

  • 1545-5017

Digital Object Identifier (DOI)

  • 10.1002/pbc.21976


  • eng

Conference Location

  • United States