T (brachyury) gene duplication confers major susceptibility to familial chordoma.
Publication
, Journal Article
Yang, XR; Ng, D; Alcorta, DA; Liebsch, NJ; Sheridan, E; Li, S; Goldstein, AM; Parry, DM; Kelley, MJ
Published in: Nat Genet
November 2009
Using high-resolution array-CGH, we identified unique duplications of a region on 6q27 in four multiplex families with at least three cases of chordoma, a cancer of presumed notochordal origin. The duplicated region contains only the T (brachyury) gene, which is important in notochord development and is expressed in most sporadic chordomas. Our findings highlight the value of screening for complex genomic rearrangements in searches for cancer-susceptibility genes.
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Published In
Nat Genet
DOI
EISSN
1546-1718
Publication Date
November 2009
Volume
41
Issue
11
Start / End Page
1176 / 1178
Location
United States
Related Subject Headings
- T-Box Domain Proteins
- Polymorphism, Single Nucleotide
- Humans
- Genome-Wide Association Study
- Genetic Predisposition to Disease
- Gene Duplication
- Fetal Proteins
- Developmental Biology
- Comparative Genomic Hybridization
- Chromosomes, Human, Pair 6
Citation
APA
Chicago
ICMJE
MLA
NLM
Yang, X. R., Ng, D., Alcorta, D. A., Liebsch, N. J., Sheridan, E., Li, S., … Kelley, M. J. (2009). T (brachyury) gene duplication confers major susceptibility to familial chordoma. Nat Genet, 41(11), 1176–1178. https://doi.org/10.1038/ng.454
Yang, Xiaohong R., David Ng, David A. Alcorta, Norbert J. Liebsch, Eamonn Sheridan, Sufeng Li, Alisa M. Goldstein, Dilys M. Parry, and Michael J. Kelley. “T (brachyury) gene duplication confers major susceptibility to familial chordoma.” Nat Genet 41, no. 11 (November 2009): 1176–78. https://doi.org/10.1038/ng.454.
Yang XR, Ng D, Alcorta DA, Liebsch NJ, Sheridan E, Li S, et al. T (brachyury) gene duplication confers major susceptibility to familial chordoma. Nat Genet. 2009 Nov;41(11):1176–8.
Yang, Xiaohong R., et al. “T (brachyury) gene duplication confers major susceptibility to familial chordoma.” Nat Genet, vol. 41, no. 11, Nov. 2009, pp. 1176–78. Pubmed, doi:10.1038/ng.454.
Yang XR, Ng D, Alcorta DA, Liebsch NJ, Sheridan E, Li S, Goldstein AM, Parry DM, Kelley MJ. T (brachyury) gene duplication confers major susceptibility to familial chordoma. Nat Genet. 2009 Nov;41(11):1176–1178.
Published In
Nat Genet
DOI
EISSN
1546-1718
Publication Date
November 2009
Volume
41
Issue
11
Start / End Page
1176 / 1178
Location
United States
Related Subject Headings
- T-Box Domain Proteins
- Polymorphism, Single Nucleotide
- Humans
- Genome-Wide Association Study
- Genetic Predisposition to Disease
- Gene Duplication
- Fetal Proteins
- Developmental Biology
- Comparative Genomic Hybridization
- Chromosomes, Human, Pair 6