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T (brachyury) gene duplication confers major susceptibility to familial chordoma.

Publication ,  Journal Article
Yang, XR; Ng, D; Alcorta, DA; Liebsch, NJ; Sheridan, E; Li, S; Goldstein, AM; Parry, DM; Kelley, MJ
Published in: Nat Genet
November 2009

Using high-resolution array-CGH, we identified unique duplications of a region on 6q27 in four multiplex families with at least three cases of chordoma, a cancer of presumed notochordal origin. The duplicated region contains only the T (brachyury) gene, which is important in notochord development and is expressed in most sporadic chordomas. Our findings highlight the value of screening for complex genomic rearrangements in searches for cancer-susceptibility genes.

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

November 2009

Volume

41

Issue

11

Start / End Page

1176 / 1178

Location

United States

Related Subject Headings

  • T-Box Domain Proteins
  • Polymorphism, Single Nucleotide
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Gene Duplication
  • Fetal Proteins
  • Developmental Biology
  • Comparative Genomic Hybridization
  • Chromosomes, Human, Pair 6
 

Citation

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Yang, X. R., Ng, D., Alcorta, D. A., Liebsch, N. J., Sheridan, E., Li, S., … Kelley, M. J. (2009). T (brachyury) gene duplication confers major susceptibility to familial chordoma. Nat Genet, 41(11), 1176–1178. https://doi.org/10.1038/ng.454
Yang, Xiaohong R., David Ng, David A. Alcorta, Norbert J. Liebsch, Eamonn Sheridan, Sufeng Li, Alisa M. Goldstein, Dilys M. Parry, and Michael J. Kelley. “T (brachyury) gene duplication confers major susceptibility to familial chordoma.Nat Genet 41, no. 11 (November 2009): 1176–78. https://doi.org/10.1038/ng.454.
Yang XR, Ng D, Alcorta DA, Liebsch NJ, Sheridan E, Li S, et al. T (brachyury) gene duplication confers major susceptibility to familial chordoma. Nat Genet. 2009 Nov;41(11):1176–8.
Yang, Xiaohong R., et al. “T (brachyury) gene duplication confers major susceptibility to familial chordoma.Nat Genet, vol. 41, no. 11, Nov. 2009, pp. 1176–78. Pubmed, doi:10.1038/ng.454.
Yang XR, Ng D, Alcorta DA, Liebsch NJ, Sheridan E, Li S, Goldstein AM, Parry DM, Kelley MJ. T (brachyury) gene duplication confers major susceptibility to familial chordoma. Nat Genet. 2009 Nov;41(11):1176–1178.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

November 2009

Volume

41

Issue

11

Start / End Page

1176 / 1178

Location

United States

Related Subject Headings

  • T-Box Domain Proteins
  • Polymorphism, Single Nucleotide
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Gene Duplication
  • Fetal Proteins
  • Developmental Biology
  • Comparative Genomic Hybridization
  • Chromosomes, Human, Pair 6