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A β-spectrin isoform from Drosophila (βH) is similar in size to vertebrate dystrophin

Publication ,  Journal Article
Dubreuil, RR; Byers, TJ; Stewart, CT; Kiehart, DP
Published in: Journal of Cell Biology
January 1, 1990

Spectrins are a major component of the membrane skeleton in many cell types where they are thought to contribute to cell form and membrane organization. Diversity among spectrin isoforms, especially their β subunits, is associated with diversity in cell shape and membrane architecture. Here we describe a spectrin isoform from Drosophila that consists of a conventional α spectrin subunit complexed with a novel high molecular weight β subunit (430 kD) that we term βH. The native αβH molecule binds actin filaments with high affinity and has a typical spectrin morphology except that it is longer than most other spectrin isoforms and includes two knoblike structures that are attributed to a unique domain of the βH subunit, βH is encoded by a different gene than the previously described Drosophila β-spectrin subunit but shows sequence similarity to β-spectrin as well as vertebrate dystrophin, a component of the membrane skeleton in muscle. By size and sequence similarity, dystrophin is more similar to this newly described β-spectrin isoform (βH) than to other members of the spectrin gene family such as α-spectrin and α-actinin.

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Published In

Journal of Cell Biology

DOI

ISSN

0021-9525

Publication Date

January 1, 1990

Volume

111

Issue

5

Start / End Page

1849 / 1858

Related Subject Headings

  • Developmental Biology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

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Dubreuil, R. R., Byers, T. J., Stewart, C. T., & Kiehart, D. P. (1990). A β-spectrin isoform from Drosophila (βH) is similar in size to vertebrate dystrophin. Journal of Cell Biology, 111(5), 1849–1858. https://doi.org/10.1083/jcb.111.5.1849
Dubreuil, R. R., T. J. Byers, C. T. Stewart, and D. P. Kiehart. “A β-spectrin isoform from Drosophila (βH) is similar in size to vertebrate dystrophin.” Journal of Cell Biology 111, no. 5 (January 1, 1990): 1849–58. https://doi.org/10.1083/jcb.111.5.1849.
Dubreuil RR, Byers TJ, Stewart CT, Kiehart DP. A β-spectrin isoform from Drosophila (βH) is similar in size to vertebrate dystrophin. Journal of Cell Biology. 1990 Jan 1;111(5):1849–58.
Dubreuil, R. R., et al. “A β-spectrin isoform from Drosophila (βH) is similar in size to vertebrate dystrophin.” Journal of Cell Biology, vol. 111, no. 5, Jan. 1990, pp. 1849–58. Scopus, doi:10.1083/jcb.111.5.1849.
Dubreuil RR, Byers TJ, Stewart CT, Kiehart DP. A β-spectrin isoform from Drosophila (βH) is similar in size to vertebrate dystrophin. Journal of Cell Biology. 1990 Jan 1;111(5):1849–1858.

Published In

Journal of Cell Biology

DOI

ISSN

0021-9525

Publication Date

January 1, 1990

Volume

111

Issue

5

Start / End Page

1849 / 1858

Related Subject Headings

  • Developmental Biology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences