Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.

Journal Article (Journal Article)

In an analogy to the potent catechol dopamine D1 agonists dihydrexidine (1) and dinapsoline (2), benzo rings were fused onto the structures of the dopamine D2-selective agonists quinelorane (3) and quinpirole (4). Each of the phenyl ring-substituted derivatives had significant affinity for D2 receptors, albeit somewhat lower than the two parent compounds, 3 and 4. Compounds with N-propyl and N-allyl substituents (5b, 5c, 6c, and 6d) had higher affinity for the D2 dopamine receptor than did their corresponding secondary amines (5a and 6a). Slightly different effects on affinity of an n-propyl and an n-allyl group in the new analogues of 3 and 4 suggest that different binding orientations may be invoked at the receptor.

Full Text

Duke Authors

Cited Authors

  • Doll, MK; Nichols, DE; Kilts, JD; Prioleau, C; Lawler, CP; Lewis, MM; Mailman, RB

Published Date

  • March 11, 1999

Published In

Volume / Issue

  • 42 / 5

Start / End Page

  • 935 - 940

PubMed ID

  • 10072690

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm9804533


  • eng

Conference Location

  • United States