Mutagenesis and the three R's in yeast.

Journal Article (Journal Article;Review)

Mutagenesis is a prerequisite for evolution and also is an important contributor to human diseases. Most mutations in actively dividing cells originate during DNA replication as errors introduced when copying an undamaged DNA template or during the bypass of DNA lesions. In addition, mutations can be introduced during the repair of DNA double-strand breaks by either homologous recombination or non-homologous end-joining pathways. Finally, although generally considered to be a very high-fidelity process, the excision repair of DNA damage may be an important contributor to mutagenesis in non-dividing cells. In this review, we will discuss the well-known contributions of DNA replication to mutagenesis in Saccharomyces cerevisiae, as well as the less-appreciated contributions of recombination and repair to mutagenesis in this organism.

Full Text

Duke Authors

Cited Authors

  • Abdulovic, A; Kim, N; Jinks-Robertson, S

Published Date

  • April 8, 2006

Published In

Volume / Issue

  • 5 / 4

Start / End Page

  • 409 - 421

PubMed ID

  • 16412705

International Standard Serial Number (ISSN)

  • 1568-7864

Digital Object Identifier (DOI)

  • 10.1016/j.dnarep.2005.11.006


  • eng

Conference Location

  • Netherlands