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Late gadolinium enhancement magnetic resonance imaging in the diagnosis and prognosis of endomyocardial fibrosis patients.

Publication ,  Journal Article
Salemi, VMC; Rochitte, CE; Shiozaki, AA; Andrade, JM; Parga, JR; de Ávila, LF; Benvenuti, LA; Cestari, IN; Picard, MH; Kim, RJ; Mady, C
Published in: Circ Cardiovasc Imaging
May 2011

BACKGROUND: Endocardial fibrous tissue (FT) deposition is a hallmark of endomyocardial fibrosis (EMF). Echocardiography is a first-line and the standard technique for the diagnosis of this disease. Although late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) allows FT characterization, its role in the diagnosis and prognosis of EMF has not been investigated. METHODS AND RESULTS: Thirty-six patients (29 women; age, 54±12 years) with EMF diagnosis after clinical evaluation and comprehensive 2-dimensional Doppler echocardiography underwent cine-CMR for assessing ventricular volumes, ejection fraction and mass, and LGE-CMR for FT characterization and quantification. Indexed FT volume (FT/body surface area) was calculated after planimetry of the 8 to 12 slices obtained in the short-axis view at end-diastole (mL/m(2)). Surgical resection of FT was performed in 16 patients. In all patients, areas of LGE were confined to the endocardium, frequently as a continuous streak from the inflow tract extending to the apex, where it was usually most prominent. There was a relation between increased FT/body surface area and worse New York Heart Association functional class and with increased probability of surgery (P<0.05). The histopathologic examination of resected FT showed typical features of EMF with extensive endocardial fibrous thickening, proliferation of small vessels, and scarce inflammatory infiltrate. In multivariate analysis, the patients with FT/body surface area >19 mL/m(2) had an increased mortality rate, with a relative risk of 10.8. CONCLUSIONS: Our study provides evidence that LGE-CMR is useful in the diagnosis and prognosis of EMF through quantification of the typical pattern of FT deposition.

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Published In

Circ Cardiovasc Imaging

DOI

EISSN

1942-0080

Publication Date

May 2011

Volume

4

Issue

3

Start / End Page

304 / 311

Location

United States

Related Subject Headings

  • Stroke Volume
  • Prognosis
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Heart Ventricles
  • Heart Failure
 

Citation

APA
Chicago
ICMJE
MLA
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Salemi, V. M. C., Rochitte, C. E., Shiozaki, A. A., Andrade, J. M., Parga, J. R., de Ávila, L. F., … Mady, C. (2011). Late gadolinium enhancement magnetic resonance imaging in the diagnosis and prognosis of endomyocardial fibrosis patients. Circ Cardiovasc Imaging, 4(3), 304–311. https://doi.org/10.1161/CIRCIMAGING.110.950675
Salemi, Vera M. C., Carlos E. Rochitte, Afonso A. Shiozaki, Joalbo M. Andrade, José R. Parga, Luiz F. de Ávila, Luiz A. Benvenuti, et al. “Late gadolinium enhancement magnetic resonance imaging in the diagnosis and prognosis of endomyocardial fibrosis patients.Circ Cardiovasc Imaging 4, no. 3 (May 2011): 304–11. https://doi.org/10.1161/CIRCIMAGING.110.950675.
Salemi VMC, Rochitte CE, Shiozaki AA, Andrade JM, Parga JR, de Ávila LF, et al. Late gadolinium enhancement magnetic resonance imaging in the diagnosis and prognosis of endomyocardial fibrosis patients. Circ Cardiovasc Imaging. 2011 May;4(3):304–11.
Salemi, Vera M. C., et al. “Late gadolinium enhancement magnetic resonance imaging in the diagnosis and prognosis of endomyocardial fibrosis patients.Circ Cardiovasc Imaging, vol. 4, no. 3, May 2011, pp. 304–11. Pubmed, doi:10.1161/CIRCIMAGING.110.950675.
Salemi VMC, Rochitte CE, Shiozaki AA, Andrade JM, Parga JR, de Ávila LF, Benvenuti LA, Cestari IN, Picard MH, Kim RJ, Mady C. Late gadolinium enhancement magnetic resonance imaging in the diagnosis and prognosis of endomyocardial fibrosis patients. Circ Cardiovasc Imaging. 2011 May;4(3):304–311.

Published In

Circ Cardiovasc Imaging

DOI

EISSN

1942-0080

Publication Date

May 2011

Volume

4

Issue

3

Start / End Page

304 / 311

Location

United States

Related Subject Headings

  • Stroke Volume
  • Prognosis
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Heart Ventricles
  • Heart Failure