Skip to main content
Journal cover image

Detection and characteristics of microvascular obstruction in reperfused acute myocardial infarction using an optimized protocol for contrast-enhanced cardiovascular magnetic resonance imaging.

Publication ,  Journal Article
Bekkers, SCAM; Backes, WH; Kim, RJ; Snoep, G; Gorgels, APM; Passos, VL; Waltenberger, J; Crijns, HJGM; Schalla, S
Published in: Eur Radiol
December 2009

Several cardiovascular magnetic resonance imaging (CMR) techniques are used to detect microvascular obstruction (MVO) after acute myocardial infarction (AMI). To determine the prevalence of MVO and gain more insight into the dynamic changes in appearance of MVO, we studied 84 consecutive patients with a reperfused AMI on average 5 and 104 days after admission, using an optimised single breath-hold 3D inversion recovery gradient echo pulse sequence (IR-GRE) protocol. Early MVO (2 min post-contrast) was detected in 53 patients (63%) and late MVO (10 min post-contrast) in 45 patients (54%; p = 0.008). The extent of MVO decreased from early to late imaging (4.3±3.2% vs. 1.8±1.8%, p<0.001) and showed a heterogeneous pattern. At baseline, patients without MVO (early and late) had a higher left ventricular ejection fraction (LVEF) than patients with persistent late MVO (56±7% vs. 48±7%, p<0.001) and LVEF was intermediate in patients with early MVO but late MVO disappearance (54±6%). During follow-up, LVEF improved in all three subgroups but remained intermediate in patients with late MVO disappearance. This optimised single breath-hold 3D IR-GRE technique for imaging MVO early and late after contrast administration is fast, accurate and allows detection of patients with intermediate remodelling at follow-up.

Duke Scholars

Published In

Eur Radiol

DOI

EISSN

1432-1084

Publication Date

December 2009

Volume

19

Issue

12

Start / End Page

2904 / 2912

Location

Germany

Related Subject Headings

  • Treatment Outcome
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Pilot Projects
  • Nuclear Medicine & Medical Imaging
  • Myocardial Reperfusion
  • Myocardial Infarction
  • Middle Aged
  • Microvessels
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bekkers, S. C. A. M., Backes, W. H., Kim, R. J., Snoep, G., Gorgels, A. P. M., Passos, V. L., … Schalla, S. (2009). Detection and characteristics of microvascular obstruction in reperfused acute myocardial infarction using an optimized protocol for contrast-enhanced cardiovascular magnetic resonance imaging. Eur Radiol, 19(12), 2904–2912. https://doi.org/10.1007/s00330-009-1489-0
Bekkers, Sebastiaan C. A. M., Walter H. Backes, Raymond J. Kim, Gabriel Snoep, Anton P. M. Gorgels, Valeria Lima Passos, Johannes Waltenberger, Harry J. G. M. Crijns, and Simon Schalla. “Detection and characteristics of microvascular obstruction in reperfused acute myocardial infarction using an optimized protocol for contrast-enhanced cardiovascular magnetic resonance imaging.Eur Radiol 19, no. 12 (December 2009): 2904–12. https://doi.org/10.1007/s00330-009-1489-0.
Bekkers, Sebastiaan C. A. M., et al. “Detection and characteristics of microvascular obstruction in reperfused acute myocardial infarction using an optimized protocol for contrast-enhanced cardiovascular magnetic resonance imaging.Eur Radiol, vol. 19, no. 12, Dec. 2009, pp. 2904–12. Pubmed, doi:10.1007/s00330-009-1489-0.
Bekkers SCAM, Backes WH, Kim RJ, Snoep G, Gorgels APM, Passos VL, Waltenberger J, Crijns HJGM, Schalla S. Detection and characteristics of microvascular obstruction in reperfused acute myocardial infarction using an optimized protocol for contrast-enhanced cardiovascular magnetic resonance imaging. Eur Radiol. 2009 Dec;19(12):2904–2912.
Journal cover image

Published In

Eur Radiol

DOI

EISSN

1432-1084

Publication Date

December 2009

Volume

19

Issue

12

Start / End Page

2904 / 2912

Location

Germany

Related Subject Headings

  • Treatment Outcome
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Pilot Projects
  • Nuclear Medicine & Medical Imaging
  • Myocardial Reperfusion
  • Myocardial Infarction
  • Middle Aged
  • Microvessels
  • Male