Hemoglobin sickle-Lepore: report of two siblings and review of the literature.


Journal Article (Review)

Hemoglobin Lepore is composed of two normal alpha-globin chains and two delta-beta fusion globin chains that result from nonhomologous crossing over of genetic material during meiosis. The doubly heterozygous condition of sickle hemoglobin with Lepore hemoglobin (Hb S-Lepore) is rare, having been described previously in only nine patients. We report two siblings with Hb S-Lepore who have similar hematologic characteristics but a marked difference in clinical severity.

Full Text

Duke Authors

Cited Authors

  • Seward, DP; Ware, RE; Kinney, TR

Published Date

  • November 1993

Published In

Volume / Issue

  • 44 / 3

Start / End Page

  • 192 - 195

PubMed ID

  • 8213769

Pubmed Central ID

  • 8213769

International Standard Serial Number (ISSN)

  • 0361-8609

Digital Object Identifier (DOI)

  • 10.1002/ajh.2830440310


  • eng

Conference Location

  • United States