Relationship of clinical severity to packed cell rheology in sickle cell anemia.

Journal Article

There is wide variation in the clinical manifestations of sickle cell disease (SCD) from one affected individual to another. Many investigators have sought to discern parameters that would explain this variability. In the present studies we have attempted to correlate the frequency of painful events and the extent of end organ failure in SCD with rheologic properties of packed suspensions of sickle cells, using a magneto-acoustic ball microrheometer developed in our laboratory. Using this device we have measured the steady-state viscosity, and the viscous and elastic moduli of cell suspensions in 16 individuals with hemoglobin SS disease who were untransfused and in their steady state. The rheologic parameters were then correlated with clinical parameters. The clinical parameters measured were emergency department visits, hospitalizations, hemoglobin, reticulocyte count, age, and end organ failure (nephropathy, avascular necrosis of bone, stroke, retinopathy, resting hypoxemia after acute chest syndrome(s), leg ulcer, and priapism with impotence). The P value for the correlation between the steady state viscosity and end organ failure was .001 with a correlation coefficient (R value) of .73. The P value for the correlation between the viscous modulus of viscosity and end organ failure was .00006 with an R value of .83. The P value for the correlation between the elastic modulus of viscosity and end organ failure was .0006 with an R value of .76. However, there was no significant correlation between any component of packed cell rheology and emergency department visits or hospitalizations for pain.

Full Text

Duke Authors

Cited Authors

  • Phillips, G; Coffey, B; Tran-Son-Tay, R; Kinney, TR; Orringer, EP; Hochmuth, RM

Published Date

  • November 15, 1991

Published In

Volume / Issue

  • 78 / 10

Start / End Page

  • 2735 - 2739

PubMed ID

  • 1824265

International Standard Serial Number (ISSN)

  • 0006-4971

Language

  • eng

Conference Location

  • United States