Long-term management of splenic sequestration in children with sickle cell disease

Journal Article

We describe our experience with 23 children with sickle cell disease and splenic sequestration crisis, emphasizing our management approaches and the patients' subsequent clinical courses. Our data illustrate that sequestration crisis may occur despite a reduction in hemoglobin S concentration to less than 30% of the total hemoglobin mass. In addition, the risk of recurrent splenic sequestration was similar for patients who received transfusion therapy and for those who were simply observed. We conclude that a short-term transfusion program to prevent recurrent splenic sequestration is of limited benefit. © 1990 Mosby-Year Book, Inc.

Full Text

Duke Authors

Cited Authors

  • Kinney, TR; Ware, RE; Schultz, WH; Filston, HC

Published Date

  • 1990

Published In

Volume / Issue

  • 117 / 2 PART 1

Start / End Page

  • 194 - 199

International Standard Serial Number (ISSN)

  • 0022-3476

Digital Object Identifier (DOI)

  • 10.1016/S0022-3476(05)80529-3