Nonblack patients with sickle cell disease have African β(s) gene cluster haplotypes
Of 18 nonblack patients with sickle cell disease, 14 had sickel cell anemia, 2 had hemoglobin SC disease, and 2 had hemoglobin S-β(o)-thalassemia. The β(s) gene cluster haplotypes that were determined in 7 patients were of African origin and were identified as Central African Republic, Central African Republic minor II, Benin, and Senegal. The haplotype Central African Republic minor II was present on the β(o)-thalassemia chromosome in 2 patients. None of 10 patients whose α-gene status was determined had α-thalassemia-2. These data strongly support the concept that the β(s) gene on chromosome 11 of these individuals is of African origin and that the α-gene locus on chromosome 16 is of white or native American origin. The clinical severity of the disease in these nonblack patients is appropriate to their haplotype without α-thalassemia-2 and is comparable with that of black patients. All persons with congenital hemolytic anemia should be examined for the presence of sickel cell disease regardless of physical appearance or ethnic background.
Rogers, ZR; Powars, DR; Kinney, TR; Williams, WD; Schroeder, WA
Journal of the American Medical Association
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