An infant girl with severe autoimmune hemolytic anemia: apparent anti-Vel specificity.


Journal Article

Autoantibodies directed against the common red-cell antigen Vel are unusual, with only 2 previous cases reported. This report describes an infant girl with steroid-resistant autoimmune hemolytic anemia whose serum contained an antibody with apparent specificity for Vel antigen. Transfusion with Vel-positive cells resulted in a massive hemolytic transfusion reaction. Survival of labelled Vel-negative cells was normal up to 8 h following transfusion, and no transfusion reaction followed subsequent use of Vel-negative cells. There was no evidence of a collagen vascular disease, an immunodeficiency syndrome, or a malignancy. Although rare, anti-Vel should be considered in unexplained autoimmune hemolytic anemia.

Full Text

Cited Authors

  • Becton, DL; Kinney, TR

Published Date

  • January 1, 1986

Published In

Volume / Issue

  • 51 / 2

Start / End Page

  • 108 - 111

PubMed ID

  • 3776136

Pubmed Central ID

  • 3776136

Electronic International Standard Serial Number (EISSN)

  • 1423-0410

International Standard Serial Number (ISSN)

  • 0042-9007

Digital Object Identifier (DOI)

  • 10.1111/j.1423-0410.1986.tb00224.x


  • eng