Platelet antibody in prolonged remission of childhood idiopathic thrombocytopenic purpura

Journal Article

Evaluations were performed in 20 patients with childhood idiopathic thrombocytopenic purpura (ITP) who remained in remission longer than 12 months. The mean duration of follow-up from diagnosis was 39 months (range 17 to 87 months). Eleven patients (four girls) in group 1 had an acute course of ITP, defined as platelet count >150×109/L within 6 months of diagnosis. Nine patients (five girls) in group 2 had a chronic course, defined as platelet count <150×109/L for ≥1 year or requiring splenectomy in an attempt to control hemorrhagic symptoms. Mean age at diagnosis and duration of follow-up were similar for both groups. Platelet count and serum (indirect) platelet-associated IgG (PAIgG) levels were normal in all 20 patients at follow-up. Both direct and indirect PAIgG levels were measured using a 125I-monoclonal anti-IgG antiglobulin assay. All had normal direct PAIgG levels, except for one patient in group 1 who had a borderline elevated value of 1209 molecules per platelet. These data suggest that the prevalence of elevated platelet antibodies is low during sustained remission without medication in patients with a history of childhood ITP. These data may be relevant for pregnant women with a history of childhood ITP, with regard to the risk of delivering an infant with thrombocytopenia secondary to transplacental passage of maternal platelet antibody. © 1985 The C. V. Mosby Company.

Duke Authors

Cited Authors

  • Ware, R; Kinney, TR; Rosse, W

Published Date

  • 1985

Published In

Volume / Issue

  • 107 / 5

Start / End Page

  • 708 - 711

PubMed ID

  • 4056968

International Standard Serial Number (ISSN)

  • 0022-3476