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Dynamic Rheological Studies of Coagulation and Fibrinolysis

Publication ,  Journal Article
Kirkpatrick, JP; McIntire, LV
Published in: Journal of Rheology
January 1, 1979

A Weissenberg rheogoniometer in the oscillatory mode was employed to determine the effect of fibrinolysis and fibrinogen degradation products (FDP) on the development of the dynamic shear moduli in coagulating platelet-free plasma (PFP) and platelet-rich plasma (PRP). While the FDP produced by incubation of PFP for 3 min with streptokinase (SK) increased the maximum shear storage modulus (G,„/) of PFP, these early FDP decreased the Gmaxof PRP clots significantly. The FDP produced at longer incubation periods reduced the G of PRP clots also. The decreased Gmaj(in PRP containing FDP appears due to FDP inhibiting the binding of polymerizing fibrin to the platelet membrane. While 10 a/ml of SK did not produce FDP or induce significant fibrinolysis, clot lysis was complete and rapid in the presence of 20 u/ml SK. Experiments with crosslinking inhibitors indicate that poorly crosslinked clots are more susceptible to fibrinolysis. In addition, a model for coagulation is presented which accurately fits the entire storage mod ulus-versus-time curve for PFP. © 1979, The Society of Rheology. All rights reserved.

Duke Scholars

Published In

Journal of Rheology

DOI

EISSN

1520-8516

ISSN

0148-6055

Publication Date

January 1, 1979

Volume

23

Issue

6

Start / End Page

769 / 787

Related Subject Headings

  • Polymers
  • 4012 Fluid mechanics and thermal engineering
  • 0915 Interdisciplinary Engineering
  • 0913 Mechanical Engineering
  • 0904 Chemical Engineering
 

Citation

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Kirkpatrick, J. P., & McIntire, L. V. (1979). Dynamic Rheological Studies of Coagulation and Fibrinolysis. Journal of Rheology, 23(6), 769–787. https://doi.org/10.1122/1.549546
Kirkpatrick, J. P., and L. V. McIntire. “Dynamic Rheological Studies of Coagulation and Fibrinolysis.” Journal of Rheology 23, no. 6 (January 1, 1979): 769–87. https://doi.org/10.1122/1.549546.
Kirkpatrick JP, McIntire LV. Dynamic Rheological Studies of Coagulation and Fibrinolysis. Journal of Rheology. 1979 Jan 1;23(6):769–87.
Kirkpatrick, J. P., and L. V. McIntire. “Dynamic Rheological Studies of Coagulation and Fibrinolysis.” Journal of Rheology, vol. 23, no. 6, Jan. 1979, pp. 769–87. Scopus, doi:10.1122/1.549546.
Kirkpatrick JP, McIntire LV. Dynamic Rheological Studies of Coagulation and Fibrinolysis. Journal of Rheology. 1979 Jan 1;23(6):769–787.

Published In

Journal of Rheology

DOI

EISSN

1520-8516

ISSN

0148-6055

Publication Date

January 1, 1979

Volume

23

Issue

6

Start / End Page

769 / 787

Related Subject Headings

  • Polymers
  • 4012 Fluid mechanics and thermal engineering
  • 0915 Interdisciplinary Engineering
  • 0913 Mechanical Engineering
  • 0904 Chemical Engineering