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Simple regional strain pattern analysis to predict response to cardiac resynchronization therapy: rationale, initial results, and advantages.

Publication ,  Journal Article
Risum, N; Jons, C; Olsen, NT; Fritz-Hansen, T; Bruun, NE; Hojgaard, MV; Valeur, N; Kronborg, MB; Kisslo, J; Sogaard, P
Published in: Am Heart J
April 2012

BACKGROUND: A classical strain pattern of early contraction in one wall and prestretching of the opposing wall followed by late contraction has previously been associated with left bundle branch block (LBBB) activation and short-term response to cardiac resynchronization therapy (CRT). Aims of this study were to establish the long-term predictive value of an LBBB-related strain pattern and to identify changes in contraction patterns during short-term and long-term CRT. METHODS AND RESULTS: Sixty-seven patients with standard CRT criteria were prospectively enrolled between early 2009 and late 2010. Echocardiography including regional strain analysis by 2-dimensional speckle tracking was performed 1 week before implantation, at day 1, and 6 months after. Response was defined as a decrease in left ventricular end-systolic volume ≥ 15%. The predictive ability of a classical pattern was compared with time-to-peak measurements from velocity and deformation analysis. Forty-three patients (65%) were classified as responders. The presence of a classical pattern showed 91% specificity and 95% sensitivity for response and performed significantly better than time-to-peak parameters in prediction of response to CRT (P < .001, all). In responders, CRT acutely increased septal longitudinal peak systolic strain (-8.7% ± 3.6% to -11.1% ± 3%, P < .001) but not in nonresponders. CONCLUSIONS: The classical pattern is highly predictive of response to CRT and superior to time-to-peak methods. Patients who obtain long-term reverse remodeling are characterized by short-term reversal of the classical strain pattern. These findings emphasize the value of recognizing potentially reversible strain patterns in selection of CRT candidates.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

April 2012

Volume

163

Issue

4

Start / End Page

697 / 704

Location

United States

Related Subject Headings

  • Ventricular Remodeling
  • Ventricular Dysfunction, Left
  • Treatment Outcome
  • Systole
  • Sensitivity and Specificity
  • Prospective Studies
  • Myocardial Contraction
  • Middle Aged
  • Male
  • Image Processing, Computer-Assisted
 

Citation

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Risum, N., Jons, C., Olsen, N. T., Fritz-Hansen, T., Bruun, N. E., Hojgaard, M. V., … Sogaard, P. (2012). Simple regional strain pattern analysis to predict response to cardiac resynchronization therapy: rationale, initial results, and advantages. Am Heart J, 163(4), 697–704. https://doi.org/10.1016/j.ahj.2012.01.025
Risum, Niels, Christian Jons, Niels T. Olsen, Thomas Fritz-Hansen, Niels E. Bruun, Michael V. Hojgaard, Nana Valeur, Mads B. Kronborg, Joseph Kisslo, and Peter Sogaard. “Simple regional strain pattern analysis to predict response to cardiac resynchronization therapy: rationale, initial results, and advantages.Am Heart J 163, no. 4 (April 2012): 697–704. https://doi.org/10.1016/j.ahj.2012.01.025.
Risum N, Jons C, Olsen NT, Fritz-Hansen T, Bruun NE, Hojgaard MV, et al. Simple regional strain pattern analysis to predict response to cardiac resynchronization therapy: rationale, initial results, and advantages. Am Heart J. 2012 Apr;163(4):697–704.
Risum, Niels, et al. “Simple regional strain pattern analysis to predict response to cardiac resynchronization therapy: rationale, initial results, and advantages.Am Heart J, vol. 163, no. 4, Apr. 2012, pp. 697–704. Pubmed, doi:10.1016/j.ahj.2012.01.025.
Risum N, Jons C, Olsen NT, Fritz-Hansen T, Bruun NE, Hojgaard MV, Valeur N, Kronborg MB, Kisslo J, Sogaard P. Simple regional strain pattern analysis to predict response to cardiac resynchronization therapy: rationale, initial results, and advantages. Am Heart J. 2012 Apr;163(4):697–704.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

April 2012

Volume

163

Issue

4

Start / End Page

697 / 704

Location

United States

Related Subject Headings

  • Ventricular Remodeling
  • Ventricular Dysfunction, Left
  • Treatment Outcome
  • Systole
  • Sensitivity and Specificity
  • Prospective Studies
  • Myocardial Contraction
  • Middle Aged
  • Male
  • Image Processing, Computer-Assisted