Activators and inhibitors of the ion channel of the NMDA receptor.

Journal Article (Review)

The involvement of the glutamate-glycine activated ion channels of the NMDA receptor in various neurophysiological processes has made this ion channel the focus of intense research. The excessive release of glutamate in a variety of neuronal hypoxic conditions implicates the NMDA receptor in a number of neuropatholological states, such as stroke, chronic pain, Parkinson's disease, Alzheimer's disease, ALS, and epilepsy, among others, thus making this receptor a prime drug target candidate. A variety of agents are known to be effective in opening and closing of the ion channels of this receptor, among the latter group of agents is the peptidic conantokins. Through the use of electrophysiological measurements with a number of cell types containing natural and recombinant subunits of the NMDA receptor, much knowledge is evolving regarding the mechanism of action of activators and inhibitors of the NMDA receptor ion channels. In addition, structure-function studies of the conantokins in these systems have been revealing in terms of their complimentary sites on the NMDA receptor. These relationships serve as the main focus of this review.

Full Text

Duke Authors

Cited Authors

  • Klein, RC; Castellino, FJ

Published Date

  • September 2001

Published In

Volume / Issue

  • 2 / 3

Start / End Page

  • 323 - 329

PubMed ID

  • 11554556

Pubmed Central ID

  • 11554556

International Standard Serial Number (ISSN)

  • 1389-4501

Digital Object Identifier (DOI)

  • 10.2174/1389450013348290


  • eng

Conference Location

  • United Arab Emirates