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RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression.

Publication ,  Journal Article
Guo, W; Zhang, L; Christopher, DM; Teng, Z-Q; Fausett, SR; Liu, C; George, OL; Klingensmith, J; Jin, P; Zhao, X
Published in: Neuron
June 9, 2011

In adult mammalian brains, neurogenesis persists in the subventricular zone of the lateral ventricles (SVZ) and the dentate gyrus (DG) of the hippocampus. Although evidence suggest that adult neurogenesis in these two regions is subjected to differential regulation, the underlying mechanism is unclear. Here, we show that the RNA-binding protein FXR2 specifically regulates DG neurogenesis by reducing the stability of Noggin mRNA. FXR2 deficiency leads to increased Noggin expression and subsequently reduced BMP signaling, which results in increased proliferation and altered fate specification of neural stem/progenitor cells in DG. In contrast, Noggin is not regulated by FXR2 in the SVZ, because Noggin expression is restricted to the ependymal cells of the lateral ventricles, where FXR2 is not expressed. Differential regulation of SVZ and DG stem cells by FXR2 may be a key component of the mechanism that governs the different neurogenic processes in these two adult germinal zones.

Duke Scholars

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

June 9, 2011

Volume

70

Issue

5

Start / End Page

924 / 938

Location

United States

Related Subject Headings

  • S100 Proteins
  • S100 Calcium Binding Protein beta Subunit
  • RNA-Binding Proteins
  • RNA, Small Interfering
  • RNA, Messenger
  • Proteoglycans
  • Protein Synthesis Inhibitors
  • Neurons
  • Neurology & Neurosurgery
  • Neurogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Guo, W., Zhang, L., Christopher, D. M., Teng, Z.-Q., Fausett, S. R., Liu, C., … Zhao, X. (2011). RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. Neuron, 70(5), 924–938. https://doi.org/10.1016/j.neuron.2011.03.027
Guo, Weixiang, Li Zhang, Devin M. Christopher, Zhao-Qian Teng, Sarah R. Fausett, Changmei Liu, Olivia L. George, John Klingensmith, Peng Jin, and Xinyu Zhao. “RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression.Neuron 70, no. 5 (June 9, 2011): 924–38. https://doi.org/10.1016/j.neuron.2011.03.027.
Guo W, Zhang L, Christopher DM, Teng Z-Q, Fausett SR, Liu C, et al. RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. Neuron. 2011 Jun 9;70(5):924–38.
Guo, Weixiang, et al. “RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression.Neuron, vol. 70, no. 5, June 2011, pp. 924–38. Pubmed, doi:10.1016/j.neuron.2011.03.027.
Guo W, Zhang L, Christopher DM, Teng Z-Q, Fausett SR, Liu C, George OL, Klingensmith J, Jin P, Zhao X. RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. Neuron. 2011 Jun 9;70(5):924–938.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

June 9, 2011

Volume

70

Issue

5

Start / End Page

924 / 938

Location

United States

Related Subject Headings

  • S100 Proteins
  • S100 Calcium Binding Protein beta Subunit
  • RNA-Binding Proteins
  • RNA, Small Interfering
  • RNA, Messenger
  • Proteoglycans
  • Protein Synthesis Inhibitors
  • Neurons
  • Neurology & Neurosurgery
  • Neurogenesis