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An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart.

Publication ,  Journal Article
Park, EJ; Watanabe, Y; Smyth, G; Miyagawa-Tomita, S; Meyers, E; Klingensmith, J; Camenisch, T; Buckingham, M; Moon, AM
Published in: Development
November 2008

In order to understand how secreted signals regulate complex morphogenetic events, it is crucial to identify their cellular targets. By conditional inactivation of Fgfr1 and Fgfr2 and overexpression of the FGF antagonist sprouty 2 in different cell types, we have dissected the role of FGF signaling during heart outflow tract development in mouse. Contrary to expectation, cardiac neural crest and endothelial cells are not primary paracrine targets. FGF signaling within second heart field mesoderm is required for remodeling of the outflow tract: when disrupted, outflow myocardium fails to produce extracellular matrix and TGFbeta and BMP signals essential for endothelial cell transformation and invasion of cardiac neural crest. We conclude that an autocrine regulatory loop, initiated by the reception of FGF signals by the mesoderm, regulates correct morphogenesis at the arterial pole of the heart. These findings provide new insight into how FGF signaling regulates context-dependent cellular responses during development.

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Published In

Development

DOI

ISSN

0950-1991

Publication Date

November 2008

Volume

135

Issue

21

Start / End Page

3599 / 3610

Location

England

Related Subject Headings

  • Transforming Growth Factor beta
  • Signal Transduction
  • Protein Serine-Threonine Kinases
  • Neural Crest
  • Myocardium
  • Morphogenesis
  • Mice
  • Mesoderm
  • Membrane Proteins
  • Intracellular Signaling Peptides and Proteins
 

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Park, E. J., Watanabe, Y., Smyth, G., Miyagawa-Tomita, S., Meyers, E., Klingensmith, J., … Moon, A. M. (2008). An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Development, 135(21), 3599–3610. https://doi.org/10.1242/dev.025437
Park, Eon Joo, Yusuke Watanabe, Graham Smyth, Sachiko Miyagawa-Tomita, Erik Meyers, John Klingensmith, Todd Camenisch, Margaret Buckingham, and Anne M. Moon. “An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart.Development 135, no. 21 (November 2008): 3599–3610. https://doi.org/10.1242/dev.025437.
Park EJ, Watanabe Y, Smyth G, Miyagawa-Tomita S, Meyers E, Klingensmith J, et al. An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Development. 2008 Nov;135(21):3599–610.
Park, Eon Joo, et al. “An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart.Development, vol. 135, no. 21, Nov. 2008, pp. 3599–610. Pubmed, doi:10.1242/dev.025437.
Park EJ, Watanabe Y, Smyth G, Miyagawa-Tomita S, Meyers E, Klingensmith J, Camenisch T, Buckingham M, Moon AM. An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Development. 2008 Nov;135(21):3599–3610.
Journal cover image

Published In

Development

DOI

ISSN

0950-1991

Publication Date

November 2008

Volume

135

Issue

21

Start / End Page

3599 / 3610

Location

England

Related Subject Headings

  • Transforming Growth Factor beta
  • Signal Transduction
  • Protein Serine-Threonine Kinases
  • Neural Crest
  • Myocardium
  • Morphogenesis
  • Mice
  • Mesoderm
  • Membrane Proteins
  • Intracellular Signaling Peptides and Proteins