Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival.

Published

Journal Article

We demonstrate here that Chordin and Noggin function as bone morphogenetic protein (BMP) antagonists in vivo to promote mammalian neural crest development. Using Chrd and Nog single and compound mutants, we find that Noggin has a major role in promoting neural crest formation, in which Chordin is partially redundant. BMP signaling is increased in dorsal tissues lacking Noggin and is further increased when Chordin is also absent. The early neural crest domain is expanded with decreased BMP antagonism in vivo. Noggin and Chordin also regulate subsequent neural crest cell emigration from the neural tube. However, reduced levels of these BMP antagonists ultimately result in perturbation of neural crest cell derived peripheral nervous system and craniofacial skeletal elements. Such defects reflect, at least in part, a function to limit apoptosis in neural crest cells. Noggin and Chordin, therefore, function together to regulate both the generation and survival of neural crest cells in mammalian development.

Full Text

Duke Authors

Cited Authors

  • Anderson, RM; Stottmann, RW; Choi, M; Klingensmith, J

Published Date

  • September 2006

Published In

Volume / Issue

  • 235 / 9

Start / End Page

  • 2507 - 2520

PubMed ID

  • 16894609

Pubmed Central ID

  • 16894609

International Standard Serial Number (ISSN)

  • 1058-8388

Digital Object Identifier (DOI)

  • 10.1002/dvdy.20891

Language

  • eng

Conference Location

  • United States