BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites.

Published

Journal Article

Bmpr1a encodes the BMP type IA receptor for bone morphogenetic proteins (BMPs), including 2 and 4. Here, we use mosaic inactivation of Bmpr1a in the epiblast of the mouse embryo (Bmpr-MORE embryos) to assess functions of this gene in mesoderm development. Unlike Bmpr1a-null embryos, which fail to gastrulate, Bmpr-MORE embryos initiate gastrulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delayed. This delay causes a more proximal distribution of cells with paraxial mesoderm character within the primitive streak, resulting in a lateral expansion of somitic mesoderm to form multiple columns. Inhibition of FGF signaling restores the normal timing of recruitment of prospective paraxial mesoderm and partially rescues the development of somites. This suggests that BMP and FGF signaling function antagonistically during paraxial mesoderm development.

Full Text

Duke Authors

Cited Authors

  • Miura, S; Davis, S; Klingensmith, J; Mishina, Y

Published Date

  • October 2006

Published In

Volume / Issue

  • 133 / 19

Start / End Page

  • 3767 - 3775

PubMed ID

  • 16943278

Pubmed Central ID

  • 16943278

International Standard Serial Number (ISSN)

  • 0950-1991

Digital Object Identifier (DOI)

  • 10.1242/dev.02552

Language

  • eng

Conference Location

  • England