Sonic hedgehog is required for cardiac outflow tract and neural crest cell development.

Journal Article (Journal Article)

The Hedgehog signaling pathway is critical for a significant number of developmental patterning events. In this study, we focus on the defects in pharyngeal arch and cardiovascular patterning present in Sonic hedgehog (Shh) null mouse embryos. Our data indicate that, in the absence of Shh, there is general failure of the pharyngeal arch development leading to cardiac and craniofacial defects. The cardiac phenotype results from arch artery and outflow tract patterning defects, as well as abnormal development of migratory neural crest cells (NCCs). The constellation of cardiovascular defects resembles a severe form of the human birth defect syndrome tetralogy of Fallot with complete pulmonary artery atresia. Previous studies have demonstrated a role for Shh in NCC survival and proliferation at later stages of development. Our data suggest that SHH signaling does not act directly on NCCs as a survival factor, but rather acts to restrict the domains that NCCs can populate during early stages (e8.5-10.5) of cardiovascular and craniofacial development.

Full Text

Duke Authors

Cited Authors

  • Washington Smoak, I; Byrd, NA; Abu-Issa, R; Goddeeris, MM; Anderson, R; Morris, J; Yamamura, K; Klingensmith, J; Meyers, EN

Published Date

  • July 15, 2005

Published In

Volume / Issue

  • 283 / 2

Start / End Page

  • 357 - 372

PubMed ID

  • 15936751

International Standard Serial Number (ISSN)

  • 0012-1606

Digital Object Identifier (DOI)

  • 10.1016/j.ydbio.2005.04.029


  • eng

Conference Location

  • United States