Skip to main content
Journal cover image

BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning.

Publication ,  Journal Article
Davis, S; Miura, S; Hill, C; Mishina, Y; Klingensmith, J
Published in: Dev Biol
June 1, 2004

BMPRIA is a receptor for bone morphogenetic proteins with high affinity for BMP2 and BMP4. Mouse embryos lacking Bmpr1a fail to gastrulate, complicating studies on the requirements for BMP signaling in germ layer development. Recent work shows that BMP4 produced in extraembryonic tissues initiates gastrulation. Here we use a conditional allele of Bmpr1a to remove BMPRIA only in the epiblast, which gives rise to all embryonic tissues. Resulting embryos are mosaics composed primarily of cells homozygous null for Bmpr1a, interspersed with heterozygous cells. Although mesoderm and endoderm do not form in Bmpr1a null embryos, these tissues are present in the mosaics and are populated with mutant cells. Thus, BMPRIA signaling in the epiblast does not restrict cells to or from any of the germ layers. Cells lacking Bmpr1a also contribute to surface ectoderm; however, from the hindbrain forward, little surface ectoderm forms and the forebrain is enlarged and convoluted. Prechordal plate, early definitive endoderm, and anterior visceral endoderm appear to be expanded, likely due to defective morphogenesis. These data suggest that the enlarged forebrain is caused in part by increased exposure of the ectoderm to signaling sources that promote anterior neural fate. Our results reveal critical roles for BMP signaling in endodermal morphogenesis and ectodermal patterning.

Duke Scholars

Published In

Dev Biol

DOI

ISSN

0012-1606

Publication Date

June 1, 2004

Volume

270

Issue

1

Start / End Page

47 / 63

Location

United States

Related Subject Headings

  • Zebrafish
  • Signal Transduction
  • Receptors, Growth Factor
  • Protein Serine-Threonine Kinases
  • Phenotype
  • Mosaicism
  • Morphogenesis
  • Mice
  • In Situ Hybridization
  • Homeodomain Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Davis, S., Miura, S., Hill, C., Mishina, Y., & Klingensmith, J. (2004). BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. Dev Biol, 270(1), 47–63. https://doi.org/10.1016/j.ydbio.2004.01.048
Davis, Shannon, Shigeto Miura, Christin Hill, Yuji Mishina, and John Klingensmith. “BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning.Dev Biol 270, no. 1 (June 1, 2004): 47–63. https://doi.org/10.1016/j.ydbio.2004.01.048.
Davis S, Miura S, Hill C, Mishina Y, Klingensmith J. BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. Dev Biol. 2004 Jun 1;270(1):47–63.
Davis, Shannon, et al. “BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning.Dev Biol, vol. 270, no. 1, June 2004, pp. 47–63. Pubmed, doi:10.1016/j.ydbio.2004.01.048.
Davis S, Miura S, Hill C, Mishina Y, Klingensmith J. BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. Dev Biol. 2004 Jun 1;270(1):47–63.
Journal cover image

Published In

Dev Biol

DOI

ISSN

0012-1606

Publication Date

June 1, 2004

Volume

270

Issue

1

Start / End Page

47 / 63

Location

United States

Related Subject Headings

  • Zebrafish
  • Signal Transduction
  • Receptors, Growth Factor
  • Protein Serine-Threonine Kinases
  • Phenotype
  • Mosaicism
  • Morphogenesis
  • Mice
  • In Situ Hybridization
  • Homeodomain Proteins