HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells.
Journal Article (Journal Article)
HIV-associated nephropathy (HIVAN) is a major cause of HIV-related morbidity and mortality. Pathogenesis involves direct infection of the glomerular and tubular epithelial cells leading to characteristic disorder. Recently, we have shown that HIV-1 Vpr causes hypertrophy, hyperploidy, and apoptosis. Here, we report that Vpr activates the DNA damage response resulting in the observed renal phenotype. Renal sections from the HIVAN transgenic mouse model and human biopsies both show an abundant DNA damage response.
Full Text
Duke Authors
Cited Authors
- Rosenstiel, PE; Chan, J; Snyder, A; Planelles, V; D'Agati, VD; Klotman, PE; Klotman, ME
Published Date
- September 24, 2009
Published In
Volume / Issue
- 23 / 15
Start / End Page
- 2054 - 2056
PubMed ID
- 19657269
Pubmed Central ID
- PMC3982604
Electronic International Standard Serial Number (EISSN)
- 1473-5571
Digital Object Identifier (DOI)
- 10.1097/QAD.0b013e32833088a0
Language
- eng
Conference Location
- England