HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells.

Journal Article (Journal Article)

HIV-associated nephropathy (HIVAN) is a major cause of HIV-related morbidity and mortality. Pathogenesis involves direct infection of the glomerular and tubular epithelial cells leading to characteristic disorder. Recently, we have shown that HIV-1 Vpr causes hypertrophy, hyperploidy, and apoptosis. Here, we report that Vpr activates the DNA damage response resulting in the observed renal phenotype. Renal sections from the HIVAN transgenic mouse model and human biopsies both show an abundant DNA damage response.

Full Text

Duke Authors

Cited Authors

  • Rosenstiel, PE; Chan, J; Snyder, A; Planelles, V; D'Agati, VD; Klotman, PE; Klotman, ME

Published Date

  • September 24, 2009

Published In

Volume / Issue

  • 23 / 15

Start / End Page

  • 2054 - 2056

PubMed ID

  • 19657269

Pubmed Central ID

  • PMC3982604

Electronic International Standard Serial Number (EISSN)

  • 1473-5571

Digital Object Identifier (DOI)

  • 10.1097/QAD.0b013e32833088a0

Language

  • eng

Conference Location

  • England