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HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells.

Publication ,  Journal Article
Rosenstiel, PE; Chan, J; Snyder, A; Planelles, V; D'Agati, VD; Klotman, PE; Klotman, ME
Published in: AIDS
September 24, 2009

HIV-associated nephropathy (HIVAN) is a major cause of HIV-related morbidity and mortality. Pathogenesis involves direct infection of the glomerular and tubular epithelial cells leading to characteristic disorder. Recently, we have shown that HIV-1 Vpr causes hypertrophy, hyperploidy, and apoptosis. Here, we report that Vpr activates the DNA damage response resulting in the observed renal phenotype. Renal sections from the HIVAN transgenic mouse model and human biopsies both show an abundant DNA damage response.

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Published In

AIDS

DOI

EISSN

1473-5571

Publication Date

September 24, 2009

Volume

23

Issue

15

Start / End Page

2054 / 2056

Location

England

Related Subject Headings

  • Virology
  • Mice, Transgenic
  • Mice
  • Kidney Tubules
  • Humans
  • HIV-1
  • Gene Products, vpr
  • Epithelial Cells
  • Disease Models, Animal
  • DNA, Viral
 

Citation

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Rosenstiel, P. E., Chan, J., Snyder, A., Planelles, V., D’Agati, V. D., Klotman, P. E., & Klotman, M. E. (2009). HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells. AIDS, 23(15), 2054–2056. https://doi.org/10.1097/QAD.0b013e32833088a0
Rosenstiel, Paul E., Justin Chan, Alexander Snyder, Vicente Planelles, Vivette D. D’Agati, Paul E. Klotman, and Mary E. Klotman. “HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells.AIDS 23, no. 15 (September 24, 2009): 2054–56. https://doi.org/10.1097/QAD.0b013e32833088a0.
Rosenstiel PE, Chan J, Snyder A, Planelles V, D’Agati VD, Klotman PE, et al. HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells. AIDS. 2009 Sep 24;23(15):2054–6.
Rosenstiel, Paul E., et al. “HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells.AIDS, vol. 23, no. 15, Sept. 2009, pp. 2054–56. Pubmed, doi:10.1097/QAD.0b013e32833088a0.
Rosenstiel PE, Chan J, Snyder A, Planelles V, D’Agati VD, Klotman PE, Klotman ME. HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells. AIDS. 2009 Sep 24;23(15):2054–2056.

Published In

AIDS

DOI

EISSN

1473-5571

Publication Date

September 24, 2009

Volume

23

Issue

15

Start / End Page

2054 / 2056

Location

England

Related Subject Headings

  • Virology
  • Mice, Transgenic
  • Mice
  • Kidney Tubules
  • Humans
  • HIV-1
  • Gene Products, vpr
  • Epithelial Cells
  • Disease Models, Animal
  • DNA, Viral