A fine line between molecular umbrella transport and ionophoric activity.
Publication
, Journal Article
Chen, W-H; Janout, V; Kondo, M; Mosoian, A; Mosoyan, G; Petrov, RR; Klotman, ME; Regen, SL
Published in: Bioconjug Chem
September 2009
A persulfated molecular umbrella derived from one spermine, four lysine, and eight deoxycholic acid molecules was found to exhibit ionophoric activity, as shown by pH discharge and Na(+) and Cl(-) transport experiments. In sharp contrast, a moderately more hydrophilic analogue derived from cholic acid showed no such ionophoric activity. Both molecular umbrellas crossed liposomal membranes by passive transport with experimental rates that were similar. These findings show how the interactions between such amphomorphic molecules and phospholipid bilayers are a sensitive function of the umbrella's hydrophilic/lipophilic balance (HLB). They also raise the possibility of exploiting molecular umbrellas in fundamentally new ways.
Duke Scholars
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Published In
Bioconjug Chem
DOI
EISSN
1520-4812
Publication Date
September 2009
Volume
20
Issue
9
Start / End Page
1711 / 1715
Location
United States
Related Subject Headings
- Spermine
- Sodium
- Organic Chemistry
- Lysine
- Liposomes
- Kinetics
- Ionophores
- Hydrophobic and Hydrophilic Interactions
- Hydrogen-Ion Concentration
- Deoxycholic Acid
Citation
APA
Chicago
ICMJE
MLA
NLM
Chen, W.-H., Janout, V., Kondo, M., Mosoian, A., Mosoyan, G., Petrov, R. R., … Regen, S. L. (2009). A fine line between molecular umbrella transport and ionophoric activity. Bioconjug Chem, 20(9), 1711–1715. https://doi.org/10.1021/bc900246u
Chen, Wen-Hua, Vaclav Janout, Masaharu Kondo, Arevik Mosoian, Goar Mosoyan, Ravil R. Petrov, Mary E. Klotman, and Steven L. Regen. “A fine line between molecular umbrella transport and ionophoric activity.” Bioconjug Chem 20, no. 9 (September 2009): 1711–15. https://doi.org/10.1021/bc900246u.
Chen W-H, Janout V, Kondo M, Mosoian A, Mosoyan G, Petrov RR, et al. A fine line between molecular umbrella transport and ionophoric activity. Bioconjug Chem. 2009 Sep;20(9):1711–5.
Chen, Wen-Hua, et al. “A fine line between molecular umbrella transport and ionophoric activity.” Bioconjug Chem, vol. 20, no. 9, Sept. 2009, pp. 1711–15. Pubmed, doi:10.1021/bc900246u.
Chen W-H, Janout V, Kondo M, Mosoian A, Mosoyan G, Petrov RR, Klotman ME, Regen SL. A fine line between molecular umbrella transport and ionophoric activity. Bioconjug Chem. 2009 Sep;20(9):1711–1715.
Published In
Bioconjug Chem
DOI
EISSN
1520-4812
Publication Date
September 2009
Volume
20
Issue
9
Start / End Page
1711 / 1715
Location
United States
Related Subject Headings
- Spermine
- Sodium
- Organic Chemistry
- Lysine
- Liposomes
- Kinetics
- Ionophores
- Hydrophobic and Hydrophilic Interactions
- Hydrogen-Ion Concentration
- Deoxycholic Acid