A fine line between molecular umbrella transport and ionophoric activity.

Journal Article (Journal Article)

A persulfated molecular umbrella derived from one spermine, four lysine, and eight deoxycholic acid molecules was found to exhibit ionophoric activity, as shown by pH discharge and Na(+) and Cl(-) transport experiments. In sharp contrast, a moderately more hydrophilic analogue derived from cholic acid showed no such ionophoric activity. Both molecular umbrellas crossed liposomal membranes by passive transport with experimental rates that were similar. These findings show how the interactions between such amphomorphic molecules and phospholipid bilayers are a sensitive function of the umbrella's hydrophilic/lipophilic balance (HLB). They also raise the possibility of exploiting molecular umbrellas in fundamentally new ways.

Full Text

Duke Authors

Cited Authors

  • Chen, W-H; Janout, V; Kondo, M; Mosoian, A; Mosoyan, G; Petrov, RR; Klotman, ME; Regen, SL

Published Date

  • September 2009

Published In

Volume / Issue

  • 20 / 9

Start / End Page

  • 1711 - 1715

PubMed ID

  • 19689127

Pubmed Central ID

  • PMC2746926

Electronic International Standard Serial Number (EISSN)

  • 1520-4812

Digital Object Identifier (DOI)

  • 10.1021/bc900246u


  • eng

Conference Location

  • United States