Defensins in innate antiviral immunity.


Journal Article (Review)

Defensins are small antimicrobial peptides that are produced by leukocytes and epithelial cells, and that have an important role in innate immunity. Recent advances in understanding the mechanisms of the antiviral action(s) of defensins indicate that they have a dual role in antiviral defence, acting directly on the virion and on the host cell. This Review focuses on the antiviral activities and mechanisms of action of mammalian defensins, and on the clinical relevance of these activities. Understanding the complex function of defensins in innate immunity against viral infection has implications for the prevention and treatment of viral disease.

Full Text

Duke Authors

Cited Authors

  • Klotman, ME; Chang, TL

Published Date

  • June 2006

Published In

Volume / Issue

  • 6 / 6

Start / End Page

  • 447 - 456

PubMed ID

  • 16724099

Pubmed Central ID

  • 16724099

International Standard Serial Number (ISSN)

  • 1474-1733

Digital Object Identifier (DOI)

  • 10.1038/nri1860


  • eng

Conference Location

  • England