Defensins in innate antiviral immunity.
Publication
, Journal Article
Klotman, ME; Chang, TL
Published in: Nat Rev Immunol
June 2006
Defensins are small antimicrobial peptides that are produced by leukocytes and epithelial cells, and that have an important role in innate immunity. Recent advances in understanding the mechanisms of the antiviral action(s) of defensins indicate that they have a dual role in antiviral defence, acting directly on the virion and on the host cell. This Review focuses on the antiviral activities and mechanisms of action of mammalian defensins, and on the clinical relevance of these activities. Understanding the complex function of defensins in innate immunity against viral infection has implications for the prevention and treatment of viral disease.
Duke Scholars
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Published In
Nat Rev Immunol
DOI
ISSN
1474-1733
Publication Date
June 2006
Volume
6
Issue
6
Start / End Page
447 / 456
Location
England
Related Subject Headings
- Virus Diseases
- Immunology
- Immunity, Innate
- Humans
- Defensins
- Animals
- 3204 Immunology
- 1107 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Klotman, M. E., & Chang, T. L. (2006). Defensins in innate antiviral immunity. Nat Rev Immunol, 6(6), 447–456. https://doi.org/10.1038/nri1860
Klotman, Mary E., and Theresa L. Chang. “Defensins in innate antiviral immunity.” Nat Rev Immunol 6, no. 6 (June 2006): 447–56. https://doi.org/10.1038/nri1860.
Klotman ME, Chang TL. Defensins in innate antiviral immunity. Nat Rev Immunol. 2006 Jun;6(6):447–56.
Klotman, Mary E., and Theresa L. Chang. “Defensins in innate antiviral immunity.” Nat Rev Immunol, vol. 6, no. 6, June 2006, pp. 447–56. Pubmed, doi:10.1038/nri1860.
Klotman ME, Chang TL. Defensins in innate antiviral immunity. Nat Rev Immunol. 2006 Jun;6(6):447–456.
Published In
Nat Rev Immunol
DOI
ISSN
1474-1733
Publication Date
June 2006
Volume
6
Issue
6
Start / End Page
447 / 456
Location
England
Related Subject Headings
- Virus Diseases
- Immunology
- Immunity, Innate
- Humans
- Defensins
- Animals
- 3204 Immunology
- 1107 Immunology