Persulfated molecular umbrellas as anti-HIV and anti-HSV agents.

Journal Article (Journal Article)

A series of persulfated molecular umbrellas have been synthesized from putrescine, spermidine, spermine, lysine, and cholic acid (1a, 2a, 3a, 4a, and 5a) and their anti-HIV and anti-HSV activities determined. Despite it size, the most active of these conjugates (5a) was able to cross phospholipid bilayers made from 1-palmitoyl-2-oleyol-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (POPG). The unique combination of anti-viral activity, an ability to cross hydrophobic barriers, a lack of cytotoxicity, and a simple three-step synthesis from biogenic starting material suggests that 5a and related conjugates may be exploitable as a novel class of anti-viral agents for systemic and topical applications.

Full Text

Duke Authors

Cited Authors

  • Jing, B; Janout, V; Herold, BC; Klotman, ME; Heald, T; Regen, SL

Published Date

  • December 15, 2004

Published In

Volume / Issue

  • 126 / 49

Start / End Page

  • 15930 - 15931

PubMed ID

  • 15584704

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja044400o


  • eng

Conference Location

  • United States