HIV envelope gp120 activates human arterial smooth muscle cells.

Published

Journal Article

There have been increasing reports of acute coronary thrombotic events in patients with HIV. Although these clinical events have been attributed primarily to dyslipidemia associated with protease inhibitor therapy, autopsy studies in children with HIV suggest the presence of an underlying arteriopathy. This study demonstrates that the HIV envelope protein, gp120, activates human arterial smooth muscle cells to express tissue factor, the initiator of the coagulation cascade. The induction of tissue factor by gp120 is mediated by two biologically relevant coreceptors for HIV infection, CXCR4 and CCR5, and is also dependent on the presence of functional CD4. Induction of tissue factor by gp120 requires activation of mitogen-activating protein kinases, activation of protein kinase C, and generation of reactive oxygen species, signaling pathways that have protean effects on smooth muscle cell physiology. The activation of smooth muscle cells by gp120 may play an important role in the vascular, thrombotic, and inflammatory responses to HIV infection.

Full Text

Duke Authors

Cited Authors

  • Schecter, AD; Berman, AB; Yi, L; Mosoian, A; McManus, CM; Berman, JW; Klotman, ME; Taubman, MB

Published Date

  • August 28, 2001

Published In

Volume / Issue

  • 98 / 18

Start / End Page

  • 10142 - 10147

PubMed ID

  • 11504923

Pubmed Central ID

  • 11504923

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.181328798

Language

  • eng

Conference Location

  • United States