Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element.

Published

Journal Article

The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.

Full Text

Duke Authors

Cited Authors

  • Li, G; Lisziewicz, J; Sun, D; Zon, G; Daefler, S; Wong-Staal, F; Gallo, RC; Klotman, ME

Published Date

  • November 1993

Published In

Volume / Issue

  • 67 / 11

Start / End Page

  • 6882 - 6888

PubMed ID

  • 8411393

Pubmed Central ID

  • 8411393

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

International Standard Serial Number (ISSN)

  • 0022-538X

Language

  • eng