Drug-eluting stents reduce restenosis rates and major adverse cardiac events, but not mortality, in patients undergoing percutaneous coronary intervention

Published

Journal Article

Question: Do drug-eluting stents reduce restenosis rates and major adverse cardiac events compared with bare-metal stents in people having percutaneous coronary intervention? Study design: Systematic review wit h meta-analysis. Main results: Elev en trials met inclusion criteria. In the first 12 months, drug-eluting stents containing paclitaxel or sirolimus did not reduce rate of death or heart attack compared with bare-metal stents (see Results table). Drug-eluting stents significantly decreased the rates of target-lesion revascularisation and major adverse cardiac events compared with bare-metal stents. The rate of angioplastic restenosis was significantly lower in people receiving drug-eluting stents (drug-eluting stent V bare-metals stent: OR 0.2, 95%CrI 0.1 to 0.4). There was no significant difference in edge stenosis between groups (drug-eluting stent V bare-metals stent: OR 1.4, 95%CrI 0.5 to 2.86). Authors' conclusions: Stents that elute paclitaxel or sirolimus significantly lower the medium-term rates of restenosis and major adverse cardiac events compared with bare-metal stents in people who have percutaneous coronary intervention. The lower rate of major cardiovascular events is entirely due to a reduction in the rate of target-lesion revascularisation, as drug-eluting stents do not reduce the rate of heart attack or death. © 2005 Elsevier Ltd. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Kong, DF

Published Date

  • January 1, 2005

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 16 - 19

International Standard Serial Number (ISSN)

  • 1744-2249

Digital Object Identifier (DOI)

  • 10.1016/j.ehbc.2004.11.030

Citation Source

  • Scopus