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Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.

Publication ,  Journal Article
Koontz, JI; Soreng, AL; Nucci, M; Kuo, FC; Pauwels, P; van Den Berghe, H; Dal Cin, P; Fletcher, JA; Sklar, J
Published in: Proc Natl Acad Sci U S A
May 22, 2001

Endometrial stromal tumors are divided into three types: benign stromal nodules, endometrial stromal sarcomas, and undifferentiated endometrial sarcomas. A variety of cytogenetic abnormalities involving chromosome 7 have been reported in endometrial stromal sarcomas, including a recurrent t(7;17)(p15;q21). We have identified two zinc finger genes, which we have termed JAZF1 and JJAZ1, at the sites of the 7p15 and 17q21 breakpoints. Analyses of tumor RNA indicate that a JAZF1/JJAZ1 fusion is present in all types of endometrial stromal tumors; however, the fusion appears to be rarer among endometrial stromal sarcomas that would be considered high-grade according to certain classification schemes. These findings suggest that the less malignant endometrial stromal tumors may evolve toward more malignant types, but that some endometrial stromal sarcomas with relatively abundant mitotic activity may compose a biologically distinct group.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

May 22, 2001

Volume

98

Issue

11

Start / End Page

6348 / 6353

Location

United States

Related Subject Headings

  • Translocation, Genetic
  • Transcription Factors
  • Sarcoma, Endometrial Stromal
  • Neoplasm Proteins
  • Molecular Sequence Data
  • Middle Aged
  • Humans
  • Female
  • Endometrial Neoplasms
  • DNA-Binding Proteins
 

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Koontz, J. I., Soreng, A. L., Nucci, M., Kuo, F. C., Pauwels, P., van Den Berghe, H., … Sklar, J. (2001). Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc Natl Acad Sci U S A, 98(11), 6348–6353. https://doi.org/10.1073/pnas.101132598
Koontz, J. I., A. L. Soreng, M. Nucci, F. C. Kuo, P. Pauwels, H. van Den Berghe, P. Dal Cin, J. A. Fletcher, and J. Sklar. “Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.Proc Natl Acad Sci U S A 98, no. 11 (May 22, 2001): 6348–53. https://doi.org/10.1073/pnas.101132598.
Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, et al. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6348–53.
Koontz, J. I., et al. “Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.Proc Natl Acad Sci U S A, vol. 98, no. 11, May 2001, pp. 6348–53. Pubmed, doi:10.1073/pnas.101132598.
Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6348–6353.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

May 22, 2001

Volume

98

Issue

11

Start / End Page

6348 / 6353

Location

United States

Related Subject Headings

  • Translocation, Genetic
  • Transcription Factors
  • Sarcoma, Endometrial Stromal
  • Neoplasm Proteins
  • Molecular Sequence Data
  • Middle Aged
  • Humans
  • Female
  • Endometrial Neoplasms
  • DNA-Binding Proteins