Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.

Published

Journal Article

Endometrial stromal tumors are divided into three types: benign stromal nodules, endometrial stromal sarcomas, and undifferentiated endometrial sarcomas. A variety of cytogenetic abnormalities involving chromosome 7 have been reported in endometrial stromal sarcomas, including a recurrent t(7;17)(p15;q21). We have identified two zinc finger genes, which we have termed JAZF1 and JJAZ1, at the sites of the 7p15 and 17q21 breakpoints. Analyses of tumor RNA indicate that a JAZF1/JJAZ1 fusion is present in all types of endometrial stromal tumors; however, the fusion appears to be rarer among endometrial stromal sarcomas that would be considered high-grade according to certain classification schemes. These findings suggest that the less malignant endometrial stromal tumors may evolve toward more malignant types, but that some endometrial stromal sarcomas with relatively abundant mitotic activity may compose a biologically distinct group.

Full Text

Duke Authors

Cited Authors

  • Koontz, JI; Soreng, AL; Nucci, M; Kuo, FC; Pauwels, P; van Den Berghe, H; Dal Cin, P; Fletcher, JA; Sklar, J

Published Date

  • May 22, 2001

Published In

Volume / Issue

  • 98 / 11

Start / End Page

  • 6348 - 6353

PubMed ID

  • 11371647

Pubmed Central ID

  • 11371647

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.101132598

Language

  • eng

Conference Location

  • United States