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Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18.

Publication ,  Journal Article
Morgan, JA; Yin, Y; Borowsky, AD; Kuo, F; Nourmand, N; Koontz, JI; Reynolds, C; Soreng, L; Griffin, CA; Graeme-Cook, F; Harris, NL; Pinkus, GS ...
Published in: Cancer Res
December 15, 1999

Lymphomas arising in mucosa-associated lymphoid tissue (MALT) are indolent B-cell tumors that have a predilection for epithelial sites and often develop in a setting of chronic inflammation or autoimmunity. As many as 50% of low-grade MALT lymphomas contain an (11;18)(q21; q21) chromosomal translocation. Using fluorescence in situ hybridization, we have analyzed the position of recombination within chromosome 18 DNA in three examples of MALT lymphoma bearing this translocation. In all three cases, the breakpoint maps to DNA in BAC b357H2, covering about 150 kb of sequence. A previously undescribed, ubiquitously expressed gene, which we refer to as MALT1, was identified within this sequence and was found to be broken in one case for which we have definitively located the position of recombination between chromosomes 18 and 11. The sequence of this gene indicates the presence of two immunoglobulin-like C2 domains and a region of partial homology to caspases, suggesting a possible role for MALT1 in the regulation of apoptosis.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

December 15, 1999

Volume

59

Issue

24

Start / End Page

6205 / 6213

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Translocation, Genetic
  • Sequence Homology, Nucleic Acid
  • Oncology & Carcinogenesis
  • Neoplasm Proteins
  • Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
  • Molecular Sequence Data
  • Lymphoma, B-Cell, Marginal Zone
  • Introns
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Morgan, J. A., Yin, Y., Borowsky, A. D., Kuo, F., Nourmand, N., Koontz, J. I., … Sklar, J. (1999). Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. Cancer Res, 59(24), 6205–6213.
Morgan, J. A., Y. Yin, A. D. Borowsky, F. Kuo, N. Nourmand, J. I. Koontz, C. Reynolds, et al. “Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18.Cancer Res 59, no. 24 (December 15, 1999): 6205–13.
Morgan JA, Yin Y, Borowsky AD, Kuo F, Nourmand N, Koontz JI, et al. Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. Cancer Res. 1999 Dec 15;59(24):6205–13.
Morgan JA, Yin Y, Borowsky AD, Kuo F, Nourmand N, Koontz JI, Reynolds C, Soreng L, Griffin CA, Graeme-Cook F, Harris NL, Weisenburger D, Pinkus GS, Fletcher JA, Sklar J. Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. Cancer Res. 1999 Dec 15;59(24):6205–6213.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

December 15, 1999

Volume

59

Issue

24

Start / End Page

6205 / 6213

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Translocation, Genetic
  • Sequence Homology, Nucleic Acid
  • Oncology & Carcinogenesis
  • Neoplasm Proteins
  • Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
  • Molecular Sequence Data
  • Lymphoma, B-Cell, Marginal Zone
  • Introns
  • Humans