Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18.

Published

Journal Article

Lymphomas arising in mucosa-associated lymphoid tissue (MALT) are indolent B-cell tumors that have a predilection for epithelial sites and often develop in a setting of chronic inflammation or autoimmunity. As many as 50% of low-grade MALT lymphomas contain an (11;18)(q21; q21) chromosomal translocation. Using fluorescence in situ hybridization, we have analyzed the position of recombination within chromosome 18 DNA in three examples of MALT lymphoma bearing this translocation. In all three cases, the breakpoint maps to DNA in BAC b357H2, covering about 150 kb of sequence. A previously undescribed, ubiquitously expressed gene, which we refer to as MALT1, was identified within this sequence and was found to be broken in one case for which we have definitively located the position of recombination between chromosomes 18 and 11. The sequence of this gene indicates the presence of two immunoglobulin-like C2 domains and a region of partial homology to caspases, suggesting a possible role for MALT1 in the regulation of apoptosis.

Full Text

Duke Authors

Cited Authors

  • Morgan, JA; Yin, Y; Borowsky, AD; Kuo, F; Nourmand, N; Koontz, JI; Reynolds, C; Soreng, L; Griffin, CA; Graeme-Cook, F; Harris, NL; Weisenburger, D; Pinkus, GS; Fletcher, JA; Sklar, J

Published Date

  • December 15, 1999

Published In

Volume / Issue

  • 59 / 24

Start / End Page

  • 6205 - 6213

PubMed ID

  • 10626814

Pubmed Central ID

  • 10626814

International Standard Serial Number (ISSN)

  • 0008-5472

Language

  • eng

Conference Location

  • United States