Mcl-1 rescues a glitch in the matrix.

Journal Article

Bcl-2 family proteins are known to control cell death and influence mitochondrial function. The function of Mcl-1, an anti-apoptotic Bcl-2 protein, is now shown to depend on its subcellular localization. Mcl-1 at the mitochondrial outer membrane inhibits mitochondrial permeabilization to block apoptosis. However, a cleaved form of Mcl-1 localizes to the mitochondrial matrix and controls inner mitochondrial morphology and oxidative phosphorylation, without directly modulating apoptosis.

Full Text

Duke Authors

Cited Authors

  • Andersen, JL; Kornbluth, S

Published Date

  • May 30, 2012

Published In

Volume / Issue

  • 14 / 6

Start / End Page

  • 563 - 565

PubMed ID

  • 22643875

Electronic International Standard Serial Number (EISSN)

  • 1476-4679

International Standard Serial Number (ISSN)

  • 1465-7392

Digital Object Identifier (DOI)

  • 10.1038/ncb2511


  • eng