Mcl-1 rescues a glitch in the matrix.
Journal Article
Bcl-2 family proteins are known to control cell death and influence mitochondrial function. The function of Mcl-1, an anti-apoptotic Bcl-2 protein, is now shown to depend on its subcellular localization. Mcl-1 at the mitochondrial outer membrane inhibits mitochondrial permeabilization to block apoptosis. However, a cleaved form of Mcl-1 localizes to the mitochondrial matrix and controls inner mitochondrial morphology and oxidative phosphorylation, without directly modulating apoptosis.
Full Text
Duke Authors
Cited Authors
- Andersen, JL; Kornbluth, S
Published Date
- May 30, 2012
Published In
Volume / Issue
- 14 / 6
Start / End Page
- 563 - 565
PubMed ID
- 22643875
Electronic International Standard Serial Number (EISSN)
- 1476-4679
International Standard Serial Number (ISSN)
- 1465-7392
Digital Object Identifier (DOI)
- 10.1038/ncb2511
Language
- eng