Life, death, and the metabolically controlled protein acetylome.

Journal Article (Review;Journal Article)

The complex signaling pathways that control cellular fate can be intimately influenced by metabolic status. Although the ability of nutrients to influence intracellular decisions has been appreciated for some time, the complex signaling mechanisms linking metabolic inputs to cell proliferation and death are not fully understood. An emerging theme in the literature is that intracellular metabolite levels can directly influence cell fate decisions through modulation of nutrient-derived protein modifications. It appears that varying the level of intracellular metabolites can alter the abundance of post-translational modifications, both by altering the availability of donor substrates and changing the activity of the nutrient-sensitive enzymes regulating these reactions. We focus here on protein acetylation, a modification that can modulate both cell proliferation and cell death in response to changes in extracellular nutrient supply.

Full Text

Duke Authors

Cited Authors

  • Johnson, ES; Kornbluth, S

Published Date

  • December 2012

Published In

Volume / Issue

  • 24 / 6

Start / End Page

  • 876 - 880

PubMed ID

  • 23103123

Electronic International Standard Serial Number (EISSN)

  • 1879-0410

International Standard Serial Number (ISSN)

  • 0955-0674

Digital Object Identifier (DOI)

  • 10.1016/


  • eng