Caspases and kinases in a death grip.


Journal Article (Review)

The complex process of apoptosis is orchestrated by caspases, a family of cysteine proteases with unique substrate specificities. Accumulating evidence suggests that cell death pathways are finely tuned by multiple signaling events, including direct phosphorylation of caspases, whereas kinases are often substrates of active caspases. Importantly, caspase-mediated cleavage of kinases can terminate prosurvival signaling or generate proapoptotic peptide fragments that help to execute the death program and facilitate packaging of the dying cells. Here, we review caspases as kinase substrates and kinases as caspase substrates and discuss how the balance between cell survival and cell death can be shifted through crosstalk between these two enzyme families.

Full Text

Duke Authors

Cited Authors

  • Kurokawa, M; Kornbluth, S

Published Date

  • September 2009

Published In

Volume / Issue

  • 138 / 5

Start / End Page

  • 838 - 854

PubMed ID

  • 19737514

Pubmed Central ID

  • 19737514

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2009.08.021


  • eng