The apoptosome: physiological, developmental, and pathological modes of regulation.

Journal Article (Review;Journal Article)

Apoptosis, a form of programmed cell death, is executed by a family of zymogenic proteases known as caspases, which cleave an array of intracellular substrates in the dying cell. Many proapoptotic stimuli trigger cytochrome c release from mitochondria, promoting the formation of a complex between Apaf-1 and caspase-9 in a caspase-activating structure known as the apoptosome. In this review, we describe knockout and knockin studies of apoptosome components, elegant structural and biochemical experiments, and analyses of the apoptosome in various cancers and other disease states, all of which have provided new insight into this critical locus of apoptotic control.

Full Text

Duke Authors

Cited Authors

  • Schafer, ZT; Kornbluth, S

Published Date

  • May 2006

Published In

Volume / Issue

  • 10 / 5

Start / End Page

  • 549 - 561

PubMed ID

  • 16678772

Electronic International Standard Serial Number (EISSN)

  • 1878-1551

International Standard Serial Number (ISSN)

  • 1534-5807

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2006.04.008


  • eng