All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners.


Journal Article (Review)

Progression through the cell cycle is governed by the periodic activation and inactivation of cyclin-dependent kinase complexes (CDK-cyclins). Although the enzymatic activity of these complexes is regulated tightly, it has recently been demonstrated that an additional facet of cell-cycle control involves the modulation of CDK-cyclin subcellular localization. Recent discoveries include the identification of nuclear transport factors responsible for ferrying some of the CDK-cyclins in and out of the nucleus, the demonstration that phosphorylation can regulate these transport processes and the establishment of potential links between cell-cycle checkpoints and the control of CDK-cyclin subcellular localization.

Full Text

Duke Authors

Cited Authors

  • Yang, J; Kornbluth, S

Published Date

  • June 1999

Published In

Volume / Issue

  • 9 / 6

Start / End Page

  • 207 - 210

PubMed ID

  • 10354564

Pubmed Central ID

  • 10354564

Electronic International Standard Serial Number (EISSN)

  • 1879-3088

International Standard Serial Number (ISSN)

  • 0962-8924

Digital Object Identifier (DOI)

  • 10.1016/s0962-8924(99)01577-9


  • eng