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Comparison of echocardiographic and cardiac magnetic resonance imaging measurements of functional single ventricular volumes, mass, and ejection fraction (from the Pediatric Heart Network Fontan Cross-Sectional Study).

Publication ,  Journal Article
Margossian, R; Schwartz, ML; Prakash, A; Wruck, L; Colan, SD; Atz, AM; Bradley, TJ; Fogel, MA; Hurwitz, LM; Marcus, E; Powell, AJ; Printz, BF ...
Published in: Am J Cardiol
August 1, 2009

Assessment of the size and function of a functional single ventricle (FSV) is a key element in the management of patients after the Fontan procedure. Measurement variability of ventricular mass, volume, and ejection fraction (EF) among observers by echocardiography and cardiac magnetic resonance imaging (CMR) and their reproducibility among readers in these patients have not been described. From the 546 patients enrolled in the Pediatric Heart Network Fontan Cross-Sectional Study (mean age 11.9 +/- 3.4 years), 100 echocardiograms and 50 CMR studies were assessed for measurement reproducibility; 124 subjects with paired studies were selected for comparison between modalities. Interobserver agreement for qualitative grading of ventricular function by echocardiography was modest for left ventricular (LV) morphology (kappa = 0.42) and weak for right ventricular (RV) morphology (kappa = 0.12). For quantitative assessment, high intraclass correlation coefficients were found for echocardiographic interobserver agreement (LV 0.87 to 0.92, RV 0.82 to 0.85) of systolic and diastolic volumes, respectively. In contrast, intraclass correlation coefficients for LV and RV mass were moderate (LV 0.78, RV 0.72). The corresponding intraclass correlation coefficients by CMR were high (LV 0.96, RV 0.85). Volumes by echocardiography averaged 70% of CMR values. Interobserver reproducibility for the EF was similar for the 2 modalities. Although the absolute mean difference between modalities for the EF was small (<2%), 95% limits of agreement were wide. In conclusion, agreement between observers of qualitative FSV function by echocardiography is modest. Measurements of FSV volume by 2-dimensional echocardiography underestimate CMR measurements, but their reproducibility is high. Echocardiographic and CMR measurements of FSV EF demonstrate similar interobserver reproducibility, whereas measurements of FSV mass and LV diastolic volume are more reproducible by CMR.

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Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

August 1, 2009

Volume

104

Issue

3

Start / End Page

419 / 428

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Stroke Volume
  • Reproducibility of Results
  • Organ Size
  • Observer Variation
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Fontan Procedure
 

Citation

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Margossian, R., Schwartz, M. L., Prakash, A., Wruck, L., Colan, S. D., Atz, A. M., … Pediatric Heart Network Investigators, . (2009). Comparison of echocardiographic and cardiac magnetic resonance imaging measurements of functional single ventricular volumes, mass, and ejection fraction (from the Pediatric Heart Network Fontan Cross-Sectional Study). Am J Cardiol, 104(3), 419–428. https://doi.org/10.1016/j.amjcard.2009.03.058
Margossian, Renee, Marcy L. Schwartz, Ashwin Prakash, Lisa Wruck, Steven D. Colan, Andrew M. Atz, Timothy J. Bradley, et al. “Comparison of echocardiographic and cardiac magnetic resonance imaging measurements of functional single ventricular volumes, mass, and ejection fraction (from the Pediatric Heart Network Fontan Cross-Sectional Study).Am J Cardiol 104, no. 3 (August 1, 2009): 419–28. https://doi.org/10.1016/j.amjcard.2009.03.058.
Margossian R, Schwartz ML, Prakash A, Wruck L, Colan SD, Atz AM, Bradley TJ, Fogel MA, Hurwitz LM, Marcus E, Powell AJ, Printz BF, Puchalski MD, Rychik J, Shirali G, Williams R, Yoo S-J, Geva T, Pediatric Heart Network Investigators. Comparison of echocardiographic and cardiac magnetic resonance imaging measurements of functional single ventricular volumes, mass, and ejection fraction (from the Pediatric Heart Network Fontan Cross-Sectional Study). Am J Cardiol. 2009 Aug 1;104(3):419–428.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

August 1, 2009

Volume

104

Issue

3

Start / End Page

419 / 428

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Stroke Volume
  • Reproducibility of Results
  • Organ Size
  • Observer Variation
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Fontan Procedure