Can prenylcysteines be exploited as ligands for mammalian multidrug-resistance transporters?

Journal Article (Journal Article;Review)

The overexpression of specific transport proteins in the membrane of many cancer cells renders these cells resistant to many therapeutic drugs. Some lipid-modified cysteine compounds inhibit one drug-transporting protein, indicating the potential of developing such compounds as therapeutic agents.

Full Text

Duke Authors

Cited Authors

  • Hurwitz, LM; Casey, PJ

Published Date

  • October 1997

Published In

Volume / Issue

  • 4 / 10

Start / End Page

  • 711 - 715

PubMed ID

  • 9375248

International Standard Serial Number (ISSN)

  • 1074-5521

Digital Object Identifier (DOI)

  • 10.1016/s1074-5521(97)90308-2


  • eng

Conference Location

  • United States