Airway remodeling from bench to bedside: current perspectives.


Journal Article (Review)

Bronchospasm and airway inflammation can lead to a constellation of irreversible changes in airway structure termed remodeling. Remodeling theory offers insight into the permanent biomechanical and pathologic alterations of asthmatic airways. Structural changes seen in asthmatic patients can include thickening of the airway wall reticular basement membrane (RBM), the presence of an abnormal elastic fiber network, and alterations in airway cartilage structure. Although steroid therapy is helpful in symptomatic control, it does not remedy structural alterations or many aspects of the inflammatory milieu. This article discusses several studies and supports the need for further investigation.

Full Text

Cited Authors

  • Slade, DJ; Kraft, M

Published Date

  • March 2006

Published In

Volume / Issue

  • 27 / 1

Start / End Page

  • 71 - vi

PubMed ID

  • 16543053

Pubmed Central ID

  • 16543053

Electronic International Standard Serial Number (EISSN)

  • 1557-8216

International Standard Serial Number (ISSN)

  • 0272-5231

Digital Object Identifier (DOI)

  • 10.1016/j.ccm.2005.11.001


  • eng