Reduction of malaria prevalence by indoor residual spraying: a meta-regression analysis.

Journal Article (Systematic Review;Journal Article)

Indoor residual spraying (IRS) has become an increasingly popular method of insecticide use for malaria control, and many recent studies have reported on its effectiveness in reducing malaria burden in a single community or region. There is a need for systematic review and integration of the published literature on IRS and the contextual determining factors of its success in controlling malaria. This study reports the findings of a meta-regression analysis based on 13 published studies, which were chosen from more than 400 articles through a systematic search and selection process. The summary relative risk for reducing malaria prevalence was 0.38 (95% confidence interval = 0.31-0.46), which indicated a risk reduction of 62%. However, an excessive degree of heterogeneity was found between the studies. The meta-regression analysis indicates that IRS is more effective with high initial prevalence, multiple rounds of spraying, use of DDT, and in regions with a combination of Plasmodium falciparum and P. vivax malaria.

Full Text

Duke Authors

Cited Authors

  • Kim, D; Fedak, K; Kramer, R

Published Date

  • July 2012

Published In

Volume / Issue

  • 87 / 1

Start / End Page

  • 117 - 124

PubMed ID

  • 22764301

Pubmed Central ID

  • PMC3391035

Electronic International Standard Serial Number (EISSN)

  • 1476-1645

International Standard Serial Number (ISSN)

  • 0002-9637

Digital Object Identifier (DOI)

  • 10.4269/ajtmh.2012.11-0620


  • eng