A pathway and approach to biomarker validation and qualification for osteoarthritis clinical trials.

Journal Article (Journal Article;Review)

This narrative review outlines the work done in other fields with regards biomarker validation and qualification and the lessons that we may learn from this experience. Defining a universally agreed upon path for biomarker validation and qualification is urgently needed to circumvent many of the hurdles faced in OA therapeutic development irrespective of whether we are discussing biochemical markers, imaging markers or other measures. This review proposes a path that may be suitable for osteoarthritis and poses some logical next steps that will take us in this direction.

Full Text

Duke Authors

Cited Authors

  • Hunter, DJ; Losina, E; Guermazi, A; Burstein, D; Lassere, MN; Kraus, V

Published Date

  • May 2010

Published In

Volume / Issue

  • 11 / 5

Start / End Page

  • 536 - 545

PubMed ID

  • 20199395

Pubmed Central ID

  • PMC3261486

Electronic International Standard Serial Number (EISSN)

  • 1873-5592

Digital Object Identifier (DOI)

  • 10.2174/138945010791011947


  • eng

Conference Location

  • United Arab Emirates