Whole blood gene expression testing for coronary artery disease in nondiabetic patients: major adverse cardiovascular events and interventions in the PREDICT trial.

Published

Journal Article

The majority of first-time angiography patients are without obstructive coronary artery disease (CAD). A blood gene expression score (GES) for obstructive CAD likelihood was validated in the PREDICT study, but its relation to major adverse cardiovascular events (MACE) and revascularization was not assessed. Patients (N = 1,160) were followed up for MACE and revascularization 1 year post-index angiography and GES, with 1,116 completing follow-up. The 30-day event rate was 23% and a further 2.2% at 12 months. The GES was associated with MACE/revascularizations (p < 0.001) and added to clinical risk scores. Patients with GES >15 trended towards increased >30 days MACE/revascularization likelihood (odds ratio = 2.59, 95% confidence interval = 0.89-9.14, p = 0.082). MACE incidence overall was 1.5% (17 of 1,116) and 3 of 17 patients had GES ≤ 15. For the total low GES group (N = 396), negative predictive value was 90% for MACE/revascularization and >99% for MACE alone, identifying a group of patients without obstructive CAD and highly unlikely to suffer MACE within 12 months.

Full Text

Duke Authors

Cited Authors

  • Rosenberg, S; Elashoff, MR; Lieu, HD; Brown, BO; Kraus, WE; Schwartz, RS; Voros, S; Ellis, SG; Waksman, R; McPherson, JA; Lansky, AJ; Topol, EJ; PREDICT Investigators,

Published Date

  • June 2012

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 366 - 374

PubMed ID

  • 22396313

Pubmed Central ID

  • 22396313

Electronic International Standard Serial Number (EISSN)

  • 1937-5395

Digital Object Identifier (DOI)

  • 10.1007/s12265-012-9353-z

Language

  • eng

Conference Location

  • United States