Adiponectin is not altered with exercise training despite enhanced insulin action


Journal Article

Adiponectin is an adipocytokine that is hypothesized to be involved in the regulation of insulin action. The purpose of the present investigation was to determine whether plasma adiponectin is altered in conjunction with enhanced insulin action with exercise training. An insulin sensitivity index (S I) and fasting levels of glucose, insulin, and adiponectin were assessed before and after 6 mo of exercise training (4 days/wk for ∼45 min at 65-80% peak 02 consumption) with no loss of body mass (PRE, 91.9 ± 3.8 kg vs. POST, 91.6 ± 3.9 kg) or fat mass (PRE, 26.5 ± 1.8 kg vs. POST, 26.7 ± 2.2 kg). Insulin action significantly (P < 0.05) improved with exercise training (S I +98%); however, plasma adiponectin concentration did not change (PRE, 6.3 ± 1.5 μg/ml vs. POST, 6.6 ± 1.8 μg/ml). In contrast, in a separate group of subjects examined before and after weight loss, there was a substantial increase in adiponectin (+281%), which was accompanied by enhanced insulin action (S I, +432%). These data suggest that adiponectin is not a contributory factor to the exercise-related improvements in insulin sensitivity.

Duke Authors

Cited Authors

  • Hulver, MW; Zheng, D; Tanner, CJ; Houmard, JA; Kraus, WE; Slentz, CA; Sinha, MK; Pories, WJ; MacDonald, KG; Lynis Dohm, G

Published Date

  • October 1, 2002

Published In

Volume / Issue

  • 283 / 4 46-4

International Standard Serial Number (ISSN)

  • 0193-1849

Citation Source

  • Scopus