Presentation and outcomes for children with bone marrow necrosis and acute lymphoblastic leukemia: a literature review.


Journal Article (Review)

Bone marrow necrosis is a rare histopathology finding with the majority of cases occurring in the setting of a hematologic malignancy. This article reports a case of diffuse marrow necrosis in a child secondary to acute lymphoblastic leukemia and summarizes the clinical features and outcomes for children with bone marrow necrosis secondary to leukemia from 20 published reports. This review demonstrated that the most common presenting features were bone pain, fever, pancytopenia, and that outcomes were less favorable when compared with those without necrosis. However, contemporary literature suggests that outcomes are similar for children who have bone marrow necrosis secondary to leukemia when compared with overall survival rates for pediatric leukemia.

Full Text

Duke Authors

Cited Authors

  • Shah, NR; Landi, DB; Kreissman, SG; Kulbachi, E; Moran, C

Published Date

  • October 2011

Published In

Volume / Issue

  • 33 / 7

Start / End Page

  • e316 - e319

PubMed ID

  • 21941136

Pubmed Central ID

  • 21941136

Electronic International Standard Serial Number (EISSN)

  • 1536-3678

Digital Object Identifier (DOI)

  • 10.1097/MPH.0b013e318223fe9b


  • eng

Conference Location

  • United States