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Computer-assisted quantification of myocardial reperfusion after primary percutaneous coronary intervention predicts functional and contrast-enhanced cardiovascular magnetic resonance outcomes in patients with ST-segment elevation myocardial infarction.

Publication ,  Journal Article
Gu, YL; Haeck, JDE; Vogelzang, M; Bilodeau, L; Krucoff, MW; Tijssen, JGP; de Winter, RJ; Zijlstra, F; Koch, KT
Published in: Catheter Cardiovasc Interv
February 1, 2011

OBJECTIVE: We investigated whether the Quantitative Blush Evaluator (QuBE) value predicts functional and contrast-enhanced cardiovascular magnetic resonance (CMR) outcomes at 4-6 months after primary percutaneous coronary intervention (PCI) inpatients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: QuBEis a computer-assisted open source program to quantify myocardial reperfusion.Although a higher QuBE value is associated with improved myocardial reperfusion measures and lower 1-year mortality, the association with intermediate functional parameters after STEMI has not yet been investigated. METHODS: QuBE values were quantified retrospectively on angiograms of patients enrolled in the ancillary CMR study of the proximal embolic protection in acute myocardial infarction and resolution of ST-elevation trial. QuBE en CMR outcomes were independently assessed by reviewers blinded to clinical data. RESULTS: A higher QuBE value was significantly associated with a smaller left ventricular (LV) end-diastolic and end-systolic volume, a higher LV ejection fraction and systolic wall thickening in the infarct area, and a smaller final infarct size and extent of transmural segments (P ≤ 0.008). In a multivariable model, including age, gender, infarct location, time to treatment, history of myocardial infarction, and postprocedural thrombolysis in myocardial infarction flow grade,only the QuBE value and infarct location remained as independent predictors of LV ejection fraction (P 5 0.018 for QuBE value). CONCLUSION: Higher QuBE values are independently associated with improved functional and contrast-enhanced CMR outcomes including LV ejection fraction at 4-6 months after primary PCI and may therefore aid in identifying high-risk patients who benefit most from adjunctive therapies sustaining myocardial function after PCI.

Duke Scholars

Published In

Catheter Cardiovasc Interv

DOI

EISSN

1522-726X

Publication Date

February 1, 2011

Volume

77

Issue

2

Start / End Page

174 / 181

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Treatment Outcome
  • Time Factors
  • Stroke Volume
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Randomized Controlled Trials as Topic
  • Radiographic Image Interpretation, Computer-Assisted
  • Predictive Value of Tests
 

Citation

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Gu, Y. L., Haeck, J. D. E., Vogelzang, M., Bilodeau, L., Krucoff, M. W., Tijssen, J. G. P., … Koch, K. T. (2011). Computer-assisted quantification of myocardial reperfusion after primary percutaneous coronary intervention predicts functional and contrast-enhanced cardiovascular magnetic resonance outcomes in patients with ST-segment elevation myocardial infarction. Catheter Cardiovasc Interv, 77(2), 174–181. https://doi.org/10.1002/ccd.22665
Gu, Youlan L., Joost D. E. Haeck, Mathijs Vogelzang, Luc Bilodeau, Mitchell W. Krucoff, Jan G. P. Tijssen, Robbert J. de Winter, Felix Zijlstra, and Karel T. Koch. “Computer-assisted quantification of myocardial reperfusion after primary percutaneous coronary intervention predicts functional and contrast-enhanced cardiovascular magnetic resonance outcomes in patients with ST-segment elevation myocardial infarction.Catheter Cardiovasc Interv 77, no. 2 (February 1, 2011): 174–81. https://doi.org/10.1002/ccd.22665.
Journal cover image

Published In

Catheter Cardiovasc Interv

DOI

EISSN

1522-726X

Publication Date

February 1, 2011

Volume

77

Issue

2

Start / End Page

174 / 181

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Treatment Outcome
  • Time Factors
  • Stroke Volume
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Randomized Controlled Trials as Topic
  • Radiographic Image Interpretation, Computer-Assisted
  • Predictive Value of Tests