The truth and consequences of the COURAGE trial.

Journal Article (Journal Article)

Percutaneous coronary intervention (PCI) has played an integral role in the therapeutic management strategies for patients who present with either acute coronary syndromes or stable angina pectoris. The COURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation) trial enrolled patients with chronic stable angina and at least 1 significant (> or =70%) angiographic coronary stenosis who were randomly assigned to an initial treatment of either PCI in conjunction with optimal medical therapy or optimal medical therapy alone. Although the initial management strategy of PCI did not reduce the risk of death, myocardial infarction, or other major cardiovascular events, improvement in angina-free status and a reduction in the requirement for subsequent revascularization was observed. An in-depth analysis of the COURAGE trial design and execution is provided.

Full Text

Duke Authors

Cited Authors

  • Kereiakes, DJ; Teirstein, PS; Sarembock, IJ; Holmes, DR; Krucoff, MW; O'Neill, WW; Waksman, R; Williams, DO; Popma, JJ; Buchbinder, M; Mehran, R; Meredith, IT; Moses, JW; Stone, GW

Published Date

  • October 16, 2007

Published In

Volume / Issue

  • 50 / 16

Start / End Page

  • 1598 - 1603

PubMed ID

  • 17936161

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2007.07.063


  • eng

Conference Location

  • United States