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Reduction of myocardial ischemia during percutaneous transluminal coronary angioplasty with oxygenated Fluosol.

Publication ,  Journal Article
Kent, KM; Cleman, MW; Cowley, MJ; Forman, MB; Jaffe, CC; Kaplan, M; King, SB; Krucoff, MW; Lassar, T; McAuley, B
Published in: Am J Cardiol
August 1, 1990

The effects of perfusion of an oxygen-carrying perfluorochemical emulsion (Fluosol) in alleviating symptoms of myocardial ischemia during balloon occlusion were examined in a multicenter trial of 245 patients. Severe anginal pain occurred less frequently in patients receiving Fluosol perfusion (21%) than in those receiving routine angioplasty (34%) (p less than 0.05). ST-segment changes at balloon deflation in routine angioplasty patients were significantly greater than in patients who received oxygenated Fluosol perfusion (2.2 +/- 1.2 vs 1.7 +/- 0.9 mm; p less than 0.03). Profound regional wall dysfunction (-561 +/- 224 U) was observed in routine angioplasty patients by 2-dimensional echocardiography. Patients receiving oxygenated Fluosol perfusion, however, maintained near baseline levels of ventricular function (-61 +/- 335 U) during occlusion (p less than 0.0001). Mean global left ventricular ejection fraction was preserved at baseline levels during balloon inflation in patients perfused with oxygenated Fluosol but decreased significantly (p less than 0.001) during occlusion in routine angioplasty patients. A total of 26 complications (19 routine group; 7 perfusion group) was reported. Adverse responses to the perfusate were infrequent, occurring in 1.6 and 2.0% of patients after the test dose and during perfusion, respectively. Thus, transcatheter perfusion with an oxygen-carrying perfluorochemical emulsion is effective in alleviating myocardial ischemia during angioplasty and can be safely administered in this patient population.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

August 1, 1990

Volume

66

Issue

3

Start / End Page

279 / 284

Location

United States

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Multicenter Studies as Topic
  • Middle Aged
  • Male
  • Humans
  • Fluorocarbons
  • Female
  • Electrocardiography
  • Echocardiography
  • Coronary Disease
 

Citation

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Kent, K. M., Cleman, M. W., Cowley, M. J., Forman, M. B., Jaffe, C. C., Kaplan, M., … McAuley, B. (1990). Reduction of myocardial ischemia during percutaneous transluminal coronary angioplasty with oxygenated Fluosol. Am J Cardiol, 66(3), 279–284. https://doi.org/10.1016/0002-9149(90)90836-p
Kent, K. M., M. W. Cleman, M. J. Cowley, M. B. Forman, C. C. Jaffe, M. Kaplan, S. B. King, M. W. Krucoff, T. Lassar, and B. McAuley. “Reduction of myocardial ischemia during percutaneous transluminal coronary angioplasty with oxygenated Fluosol.Am J Cardiol 66, no. 3 (August 1, 1990): 279–84. https://doi.org/10.1016/0002-9149(90)90836-p.
Kent KM, Cleman MW, Cowley MJ, Forman MB, Jaffe CC, Kaplan M, et al. Reduction of myocardial ischemia during percutaneous transluminal coronary angioplasty with oxygenated Fluosol. Am J Cardiol. 1990 Aug 1;66(3):279–84.
Kent, K. M., et al. “Reduction of myocardial ischemia during percutaneous transluminal coronary angioplasty with oxygenated Fluosol.Am J Cardiol, vol. 66, no. 3, Aug. 1990, pp. 279–84. Pubmed, doi:10.1016/0002-9149(90)90836-p.
Kent KM, Cleman MW, Cowley MJ, Forman MB, Jaffe CC, Kaplan M, King SB, Krucoff MW, Lassar T, McAuley B. Reduction of myocardial ischemia during percutaneous transluminal coronary angioplasty with oxygenated Fluosol. Am J Cardiol. 1990 Aug 1;66(3):279–284.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

August 1, 1990

Volume

66

Issue

3

Start / End Page

279 / 284

Location

United States

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Multicenter Studies as Topic
  • Middle Aged
  • Male
  • Humans
  • Fluorocarbons
  • Female
  • Electrocardiography
  • Echocardiography
  • Coronary Disease