The corticotropin-releasing hormone test in patients with posttraumatic stress disorder.

Journal Article (Journal Article)

To evaluate the hypothalamic-pituitary-adrenal (HPA) axis in patients with posttraumatic stress disorder (PTSD), we measured adrenocorticotropin hormone (ACTH) and cortisol responses following administration of corticotropin-releasing hormone (CRH) in 8 combat veterans with chronic PTSD. The PTSD patients had a significantly lower ACTH response to CRH compared to a control group of normal volunteers. Blunted ACTH responses occurred in patients with PTSD alone, as well as those PTSD patients who also had major depression. The cortisol response, although reduced, was not significantly different from normal. The blunted ACTH response to CRH in PTSD patients is similar to that seen in other psychiatric disorders, such as depression, panic disorder, and anorexia nervosa.

Full Text

Duke Authors

Cited Authors

  • Smith, MA; Davidson, J; Ritchie, JC; Kudler, H; Lipper, S; Chappell, P; Nemeroff, CB

Published Date

  • August 1, 1989

Published In

Volume / Issue

  • 26 / 4

Start / End Page

  • 349 - 355

PubMed ID

  • 2548631

Pubmed Central ID

  • 2548631

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/0006-3223(89)90050-4


  • eng

Conference Location

  • United States