Individual differences in cocaine conditioned taste aversion are developmentally stable and independent of locomotor effects of cocaine.

Published

Journal Article

Drugs of abuse induce complex motivational states in their users which have been shown to vary developmentally. In addition to developmental variation, interindividual variation in the rewarding and aversive effects of drugs of abuse is an important consideration. A rat model was used to assess whether the conditioned rewarding/aversive effects of cocaine were maintained as individuals matured from adolescence into adulthood. We tested rats in the cocaine conditioned taste aversion task as adolescents and again in adulthood. We observed a wide range of approach/avoidance behaviors in this task, and also observed that the relative interindividual differences in approach/avoidance are remarkably stable across the two developmental stages. Furthermore, we observed that these interindividual differences are not attributable to individual differences in cocaine-induced locomotor effects or individual differences in blood or brain cocaine levels. Taken together, these findings indicate that sensitivity to cocaine’s motivational effects is stable across development and part of a unique neurological process.

Full Text

Duke Authors

Cited Authors

  • Drescher, C; Foscue, EP; Kuhn, CM; Schramm-Sapyta, NL

Published Date

  • October 2011

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 600 - 605

PubMed ID

  • 21927632

Pubmed Central ID

  • 21927632

Electronic International Standard Serial Number (EISSN)

  • 1878-9307

Digital Object Identifier (DOI)

  • 10.1016/j.dcn.2011.05.004

Language

  • eng

Conference Location

  • Netherlands